The interaction of capsaicin with microsomal drug-metabolizing systems was assessed to
determine the role that bioactivation of capsaicin may play in the induction of hepatotoxicity …

A new metabolic oxidation pathway of capsaicin (N-[(4-hydroxy-3-methoxyphenyl)-methyl]-8-
methyl-(E)-6-nonenamide), a major pungent and pharmacologically active principle of hot …

SUMMARY Administration of capsaicin (8—methyl—N-vanilly1—6—nonenamide) to
neonatal rats gives a long—lasting insensitivity to chemical irritants, and its potential as a …

Capsaicin activates poorly myelinated primary afferent neurons, many of which are
polymodal nociceptors. Activation is accompanied by membrane depolarization and the …

Gastrointestinal absorption of capsaicin and dihydrocapsaicin was studied in rats in vivo and
in situ. Rapid absorption of capsaicin or dihydrocapsaicin from stomach and small intestine …

Capsaicin, a natural product of Capsicum species, induces excitation of pain perception at
nociceptive terminals. Our previous studies have shown that capsaicin inhibits protein …

This study was performed to examine the metabolism and absorption of intragastrically
administered capsaicinoids in the anaesthetized rat.[3 H]-dihydrocapsaicin ([3 H]-DHC) and …

Over the past several decades capsaicin, a natural product of certain species of red pepper,
has been found to have a broad range of physiological effects in adult animals. Recent …

Capsaicin is a common dietary constituent and a popular homeopathic treatment for chronic
pain. Exposure to capsaicin has been shown to cause various dose-dependent acute …

The effects of capsaicin, the major pungent ingredient of hot peppers, were assessed on
sensory neuron neuropeptide levels and on sensory function in the adult guinea pig …