The prenatal period of germ cell development is a key time of epigenetic programming in the
male, a window of development that has been shown to be influenced by maternal factors …

Embryogenesis is tightly regulated by multiple levels of epigenetic regulation such as DNA
methylation, histone modification, and chromatin remodeling. DNA methylation patterns are …

DNA methylation is dynamically remodelled during the mammalian life cycle through distinct
phases of reprogramming and de novo methylation. These events enable the acquisition of …

In mammals, active demethylation of cytosine methylation in the sperm genome prior to
forming a functional zygotic nucleus is thought to be a function of the oocyte cytoplasm …

Mammalian development is associated with considerable changes in global DNA
methylation levels at times of genomic reprogramming. Normal DNA methylation is essential …

There is species divergence in control of DNA methylation during preimplantation
development. The exact pattern of methylation in the bovine embryo has not been …

The first crucial step in the developmental program occurs during pre-implantation, the time
after the oocyte has been fertilized and before the embryo implants in the uterus. This period …

DNA methylation is essential for the control of a number of biological mechanisms in
mammals [1]. Mammalian development is accompanied by two major waves of genome …

Genes constitute only a small proportion of the mammalian genome, the majority of which is
composed of non-genic repetitive elements including interspersed repeats and satellites. A …

Critical epigenetic regulation of primate embryogenesis entails DNA methylome changes.
Here we report genome-wide composition, patterning, and stage-specific dynamics of DNA …