Active demethylation of cytosine residues in the sperm genome before forming a functional
zygotic nucleus is thought to be an important function of the oocyte cytoplasm for …

DNA methylation constitutes an important epigenetic factor in the control of genetic
information. In this study, we analyzed expression of the DNA methyltransferase gene and …

DNA methylation is a major epigenetic modification that undergoes dramatic changes in two
epigenetic reprogramming windows during development: first in preimplantation embryos …

ABSTRACT DNA methylation reprogramming (DMR) during preimplantation development
erases differentiation-associated, unessential epigenetic information accumulated during …

The initial cohort of mammalian gametes is established by the proliferation of primordial
germ cells in the early embryo. Primordial germ cells first appear in extraembyronic tissues …

Background Changes in DNA methylation in the mammalian genome during development
are frequent events and play major roles regulating gene expression and other …

ABSTRACT DNA methylation in the oocyte has a particular significance: it may contribute to
gene regulation in the oocyte and marks specific genes for activity in the embryo, as in the …

Background Uncovering mechanisms of epigenome evolution is an essential step towards
understanding the evolution of different cellular phenotypes. While studies have confirmed …

Embryonic development is a complex and dynamic process with frequent changes in gene
expression, ultimately leading to cellular differentiation and commitment of various cell lines …

DNA methylation patterns are reprogrammed in primordial germ cells and in preimplantation
embryos by demethylation and subsequent de novo methylation. It has been suggested that …