Pancreatic cancer is a leading cause of mortality worldwide due to the difficulty of detecting
early-stage disease and our poor understanding of the mediators that drive progression of …

Rationale: Endoplasmic reticulum oxidoreductase 1 alpha (ERO1L) is an endoplasmic
reticulum (ER) luminal glycoprotein that has a role in the formation of disulfide bonds of …

Pancreatic cancer is a lethal malignancy with an extremely poor prognosis. Although many
genes and noncoding RNAs have been found to regulate its progression, more regulators …

Endoplasmic reticulum disulphide oxidase 1α (ERO1α) is an oxidase localized in the
endoplasmic reticulum that plays a role in the formation of disulphide bonds of secreted and …

Purpose Gastric cancer is the second leading cause of cancer-related death worldwide.
Although surgery is the standard curative treatment for gastric cancer, relapse occurs in a …

Background Hypoxia is a characteristic of the tumor microenvironments within pancreatic
cancer (PC), which has been linked to its malignancy. Recently, hypoxia has been reported …

Solid tumors are often characterized by a hypoxic microenvironment which contributes,
through the hypoxia-inducible factor HIF-1, to the invasion-metastasis cascade …

Background Tumor hypoxia is associated with metastasis and resistance to chemotherapy
and radiotherapy. Genes involved in oxygen-sensing are clinically relevant and have …

Lung cancer is the leading cause of cancer‐related death worldwide. Previous studies
revealed that endoplasmic reticulum oxidoreductase 1 alpha (ERO1L) played critical roles in …

Many primary-tumor subregions exhibit low levels of molecular oxygen and restricted access
to nutrients due to poor vascularization in the tissue, phenomenon known as hypoxia …