Function and information content of DNA methylation
D Schübeler - Nature, 2015 - nature.com
Cytosine methylation is a DNA modification generally associated with transcriptional
silencing. Factors that regulate methylation have been linked to human disease, yet how …
silencing. Factors that regulate methylation have been linked to human disease, yet how …
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity
K Williams, J Christensen, MT Pedersen, JV Johansen… - Nature, 2011 - nature.com
Enzymes catalysing the methylation of the 5-position of cytosine (mC) have essential roles in
regulating gene expression and maintaining cellular identity. Recently, TET1 was found to …
regulating gene expression and maintaining cellular identity. Recently, TET1 was found to …
Genomic patterns of DNA methylation: targets and function of an epigenetic mark
M Weber, D Schübeler - Current opinion in cell biology, 2007 - Elsevier
Methylation of cytosines can mediate epigenetic gene silencing and is the only known DNA
modification in eukaryotes. Recent efforts to map DNA methylation across mammalian …
modification in eukaryotes. Recent efforts to map DNA methylation across mammalian …
[HTML][HTML] A genome-scale map of DNA methylation turnover identifies site-specific dependencies of DNMT and TET activity
PA Ginno, D Gaidatzis, A Feldmann, L Hoerner… - Nature …, 2020 - nature.com
DNA methylation is considered a stable epigenetic mark, yet methylation patterns can vary
during differentiation and in diseases such as cancer. Local levels of DNA methylation result …
during differentiation and in diseases such as cancer. Local levels of DNA methylation result …
Human DNA methylomes at base resolution show widespread epigenomic differences
DNA cytosine methylation is a central epigenetic modification that has essential roles in
cellular processes including genome regulation, development and disease. Here we …
cellular processes including genome regulation, development and disease. Here we …
DNMT1-interacting RNAs block gene-specific DNA methylation
A Di Ruscio, AK Ebralidze, T Benoukraf, G Amabile… - Nature, 2013 - nature.com
DNA methylation was first described almost a century ago; however, the rules governing its
establishment and maintenance remain elusive. Here we present data demonstrating that …
establishment and maintenance remain elusive. Here we present data demonstrating that …
DNA-binding factors shape the mouse methylome at distal regulatory regions
Methylation of cytosines is an essential epigenetic modification in mammalian genomes, yet
the rules that govern methylation patterns remain largely elusive. To gain insights into this …
the rules that govern methylation patterns remain largely elusive. To gain insights into this …
[HTML][HTML] The concurrence of DNA methylation and demethylation is associated with transcription regulation
The mammalian DNA methylome is formed by two antagonizing processes, methylation by
DNA methyltransferases (DNMT) and demethylation by ten-eleven translocation (TET) …
DNA methyltransferases (DNMT) and demethylation by ten-eleven translocation (TET) …
Epigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues
G Landan, NM Cohen, Z Mukamel, A Bar… - Nature …, 2012 - nature.com
DNA methylation has been comprehensively profiled in normal and cancer cells, but the
dynamics that form, maintain and reprogram differentially methylated regions remain …
dynamics that form, maintain and reprogram differentially methylated regions remain …
DNA methylation: TET proteins—guardians of CpG islands?
K Williams, J Christensen, K Helin - EMBO reports, 2012 - embopress.org
DNA methylation is involved in key cellular processes, including X‐chromosome
inactivation, imprinting and transcriptional silencing of specific genes and repetitive …
inactivation, imprinting and transcriptional silencing of specific genes and repetitive …