The inhibitory mechanisms of losartan and vitamin D on amiodarone‐induced lung inflammation in rats: Role of mitogen‐activated protein kinases/activator protein‐1

S Al‐Hassan, H Attia, H Alomar… - Journal of Biochemical …, 2021 - Wiley Online Library
Amiodarone (AMD), an antiarrhythmic drug, is used cautiously due to its lung toxicity that is
characterized by alveolar inflammation followed by fatal fibrosis. AMD induces lung …

Impact of Olmesartan Medoxomil on Amiodarone‐Induced Pulmonary Toxicity in Rats: Focus on Transforming Growth Factor‐ß1

AAI Sharaf El‐Din, OM Abd Allah - Basic & clinical …, 2016 - Wiley Online Library
Amiodarone (AD) is one of the most frequently prescribed anti‐arrhythmic agents worldwide,
but its effectiveness is limited due to the development of pulmonary toxicity. Several lines of …

A Mechanistic Study on the Amiodarone‐Induced Pulmonary Toxicity

B Al-Shammari, M Khalifa, SA Bakheet… - … medicine and cellular …, 2016 - Wiley Online Library
Amiodarone‐(AM‐) induced pulmonary toxicity (AIPT) is still a matter of research and is
poorly understood. In attempting to resolve this issue, we treated Sprague‐Dawley rats with …

Induction of c-jun and TGF-β1 in Fischer 344 rats during amiodarone-induced pulmonary fibrosis

WH Chung, BM Bennett, WJ Racz… - … of Physiology-Lung …, 2001 - journals.physiology.org
Amiodarone (AM) is an antidysrhythmic agent with a propensity to cause pulmonary toxicity,
including potentially fatal fibrosis. In the present study, the potential roles of c-Jun and …

Altered surfactant homeostasis and alveolar epithelial cell stress in amiodarone-induced lung fibrosis

P Mahavadi, I Henneke, C Ruppert… - Toxicological …, 2014 - academic.oup.com
Amiodarone (AD) is a highly efficient antiarrhythmic drug with potentially serious side effects.
Severe pulmonary toxicity is reported in patients receiving AD even at low doses and may …

Investigation of the role of oxidative stress in amiodarone-induced pulmonary toxicity in the hamster

RG Leeder, JF Brien, TE Massey - Canadian journal of …, 1994 - cdnsciencepub.com
Associated with amiodarone (AM) therapy is pneumonitis, which may progress to life-
threatening pulmonary fibrosis. Although the etiology of amiodarone-induced pulmonary …

Amiodarone-induced pulmonary toxicity in Fischer rats: release of tumor necrosis factor alpha and transforming growth factor beta by pulmonary alveolar …

PG Reinhart, CG Gairola - Journal of toxicology and environmental …, 1997 - Taylor & Francis
Amiodarone is an antiarrhythmic drug with numerous side effects, the most serious being the
development of pulmonary toxicity. We have previously reported that a single intratra cheal …

A characterization of amiodarone-induced pulmonary toxicity in F344 rats and identification of surfactant protein-D as a potential biomarker for the development of the …

MD Taylor, K Van Dyke, LL Bowman, PR Miles… - Toxicology and applied …, 2000 - Elsevier
Amiodarone (AD) is gaining support as a first-line antiarrhythmic drug despite its potentially
fatal pulmonary toxicity involving inflammation and fibrosis. The goals of this study were to …

Amiodarone induces epithelial-mesenchymal transition in A549 cells via activation of TGF-β1

J Weng, H Chen, H Wu, M Tu, Z Wang… - Drug and Chemical …, 2020 - Taylor & Francis
Amiodarone is a high effectiveness anti-arrhythmia agent which is able to induce pulmonary
fibrosis. Many studies have shown that the epithelial-mesenchymal transition (EMT) was a …

Amiodarone-induced pulmonary inflammation

BD Wilson, CE Clarkson, ML Lippmann - Am Rev Respir Dis, 1991 - atsjournals.org
Toinvestigate the hypotheses that amiodarone-induced pulmonary inflammation may be
related to direct drug toxicity, groups of 10or more Wistar rats were fed amiodarone by …