Amiodarone-induced pulmonary toxicity is a serious side-effect, but the underlying
molecular mechanisms remain unclear. We examined phospholipidosis and apoptosis in rat …

To determine whether a hypersensitivity reaction played a role in amiodarone-induced
pulmonary inflammation and affected humoral immunity, we examined pulmonary …

Earlier work in this laboratory showed that amiodarone induces apoptosis in alveolar
epithelial cells by a mechanism inhibitable by angiotensin system antagonists. A variety of …

Amiodarone (AMD), a class III antiarrhythmic drug, causes idiosyncratic hepatotoxicity in
human patients. We demonstrated previously that tumor necrosis factor-alpha (TNF-α) plays …

Background: The fruits of Aronia melanocarpa (Michx.) Elliot is extremely rich in biologically
active polyphenols. Objective: We studied the protective effect of A. melanocarpa fruit juice …

Amiodarone (AM) is an effective antidysrhythmic agent, the use of which is limited because
of the drug′ s potential for causing life-threatening pulmonary fibrosis. Oxidative stress …

Treatment of humans with the antiarrhythmic drug, amiodarone (AD), may result in the
development of pulmonary toxicity. To characterize this response, male Fischer 344 rats …

Background Amiodarone (AMD) and its metabolite N-desethylamiodarone can cause some
adverse effects, which include pulmonary toxicity. Some studies suggest that mitochondrial …

Amiodarone is a highly effective anti-arrhythmic drug, used in the treatment of cardiac
arrhythmias. However, it is of a limited use due its serious side effects especially lung …

Amiodarone is a high effectiveness anti-arrhythmia agent which is able to induce pulmonary
fibrosis. Many studies have shown that the epithelial-mesenchymal transition (EMT) was a …