Acute pulmonary inflammation in hamsters following intratracheal administration of amiodarone

TL Blake, MJ Reasor - Inflammation, 1995 - Springer
The use of the antiarrythmic drug amiodarone (AD) has been limited by the propensity of the
drug to cause severe lung damage. AD has been shown to produce a transient pulmonary …

[HTML][HTML] Amiodarone induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts

J Weng, M Tu, P Wang, X Zhou, C Wang, X Wan… - Biomedicine & …, 2019 - Elsevier
Amiodarone is a potent antidysrhythmic agent that can cause potentially life-threatening
pulmonary fibrosis. Accumulating evidence has demonstrated that myofibroblast …

[PDF][PDF] Protection against lung toxicity induced by Amiodarone in Albino rats by fish oil

NA Sarg, KM Kamal - Journal of American Science, 2019 - bu.edu.eg
Background: Amiodarone (AD) is a strong anti-arrhythmic drug but has adverse reactions on
different organs. Fish oil which is rich in Omega-3 polyunsaturated fatty acids (omega-3 …

Modulation of both activator protein-1 and nuclear factor-kappa B signal transduction of human T cells by amiodarone

SM Cheng, WH Lin, CS Lin, LJ Ho… - Experimental …, 2015 - journals.sagepub.com
Amiodarone, a common and effective antiarrhythmic drug, has been reported to have anti-
inflammatory effects such as reducing the activation and movement of neutrophils. However …

Pulmonary responses to amiodarone in hamsters: Comparison of intratracheal and oral administrations

TL Blake, MJ Reasor - Toxicology and applied pharmacology, 1995 - Elsevier
Amiodarone (AD) has been shown to produce a transient pulmonary fibrosis in hamsters
after intratracheal (it) instillation. The goal of this study was to examine bronchoalveolar …

[PDF][PDF] The possible ameliorative effect of selenium and vitamins combination against amiodarone-induced alveolar damage in albino rat: histological and …

AA Mahdy - J Am Sci, 2014 - researchgate.net
Background: Chronic interstitial pneumonitis is the most common presentation of
amiodarone-induced pulmonary disease. Aim of the work: To throw a light on the damage of …

Effects of In Vitro Amiodarone Exposureon Alveolar Macrophage Inflammatory Mediator Production

RJ Zitnik, JAD Cooper Jr, JA Rankin… - The American journal of …, 1992 - Elsevier
Administration of amiodarone, although often lifesaving, is associated with pulmonary side
effects. Patients with amiodarone pulmonary toxicity can present with either a chronic …

Effects of dietary vitamin E supplementation on pulmonary morphology and collagen deposition in amiodarone-and vehicle-treated hamsters

JW Card, RG Leeder, WJ Racz, JF Brien, TM Bray… - Toxicology, 1999 - Elsevier
Amiodarone (AM) is a potent antidysrhythmic agent that is limited in clinical use by its
adverse effects, including potentially life-threatening AM-induced pulmonary toxicity (AIPT) …

Evaluation of reactive oxygen species involvement in amiodarone pulmonary toxicity in vivo and in vitro

RG Leeder, E Rafeiro, JF Brien… - Journal of …, 1996 - Wiley Online Library
Amiodarone (AM) is an effective antidysrhythmic agent, restricted in use by the development
of adverse effects, including potentially fatal AM‐induced pulmonary toxicity (AIPT). Although …

Mechanisms of amiodarone and desethylamiodarone cytotoxicity in nontransformed human peripheral lung epithelial cells

JE Mulder, JF Brien, WJ Racz, T Takahashi… - … of Pharmacology and …, 2011 - ASPET
Amiodarone (AM) is a potent antidysrhythmic agent that can cause potentially life-
threatening pulmonary fibrosis, and N-desethylamiodarone (DEA), an AM metabolite, may …