Amiodarone is a widely used anti-arrhythmic agent. We have investigated alterations in the
glutathione (GSH) level and the activities of anti-oxidative enzymes (superoxide dismutase …

Amiodarone (AM) is a potent antidysrhythmic agent that can cause potentially life-
threatening pulmonary fibrosis, and N-desethylamiodarone (DEA), an AM metabolite, may …

Amiodarone is a potent antiarrhythmic agent with a number of side-effects, the most serious
being the development of pulmonary toxicity. The purpose of the study was to determine if a …

Conclusions Since the discovery of amiodarone over 30 years ago, the mechanisms
underlying serious adverse effects remain to be resolved and still limit drug usefulness …

Therapeutic use of amiodarone (AD), an effective antiarrhythmic drug, is associated with
serious pulmonary toxicity (eg, fibrosis and phospholipidosis). In the present study, we …

It has been reported that amiodarone induces disorders of alveolar macrophages and pul
monary fibrosis, but the mechanism is not well-understood. This study was performed to …

The antiarrhythmic amiodarone (AM) and its metabolite desethylamiodarone (Des) are
known to cause AM-induced pulmonary toxicity, but the mechanisms underlying this …

Amiodarone (AM) is an effective anti-arrhythmic drug. We investigated the role of mast cells
and macrophages on AM induced pulmonary fibrosis and the action of atorvastatin on this …

Acute lung injury (ALI) is a common and devastating clinical disorder with a high mortality
rate and no specific therapy. The pathophysiology of ALI is characterized by increased …

Previous work from this laboratory has shown that amiodarone induces alveolar epithelial
cell apoptosis that was abrogated by antagonists of angiotensin II. In this study, amiodarone …