Objective: The purpose of this study was to evaluate the effect of atorvastatin administration
on amiodarone-induced pulmonary fibrosis in rats. Materials and Methods: Thirty-six male …

Amiodarone is an effective antidysrhythmic agent, restricted in use by the development of
pulmonary toxicity. Several in vivo animal models have been used to study amiodarone …

Abstract Objective Astragaloside IV (AS IV) is antioxidant and anti-inflammatory product,
which is extracted from the Chinese herb Astragalus membranaceus. It is widely used in a …

OBJECTIVE: Ventilator-induced lung injury (VILI) remains a challenge. This study was
designed to investigate the effects of ambroxol on VILI and the underlying mechanisms in a …

Associated with amiodarone use is pneumonitis which may progress to life-threatening
pulmonary fibrosis. Desethylamiodarone, a metabolite, whose role in the etiology of …

Although, the antiarrhythmic effect of amiodarone (AMD) is well characterized, the
mechanism of its toxicity on extracardiac tissues is still poorly understood. Several …

Amiodarone is a potent anti-arrhythmic drug used for the treatment of cardiac arrhythmias.
Although, the effects of amiodarone are well characterized on post-ischemic heart and …

Evidence suggests that an imbalance between oxidation and antioxidation is involved in the
pathogenesis of acute lung injury/acute respiratory distress syndrome (ALI/ARDS) …

Amiodarone (AM) is an efficacious antidysrhythmic agent that is limited clinically by
numerous adverse effects. Of greatest concern is AM-induced pulmonary toxicity (AIPT) due …

Amiodarone is an orally active antiarrhythmic drug generally used throughout the world,
causing pulmonary toxicity as one of its most harmful side effects. The efficacy of two …