Effects of amiodarone on lung tissue mechanics and parenchyma remodeling

FB Santos, CSNB Garcia, DG Xisto, EM Negri… - Respiratory physiology …, 2008 - Elsevier
We studied the results of chronic oral administration of amiodarone on in vitro lung tissue
mechanics, light and electron microscopy. Fifteen Wistar male rats were divided into three …

Artemisia argyi attenuates airway inflammation in lipopolysaccharide induced acute lung injury model

NR Shin, SH Park, JW Ko, HW Ryu, SH Jeong… - Laboratory animal …, 2017 - Springer
Artemisia argyi is used as a health supplement, tea, and food source in Korea. This study
aimed to evaluate the effect of Artemisia argyi (AA) and its active compound …

Response of rat lungs to amiodarone: preferential accumulation of amiodarone and desethylamiodarone in alveolar macrophages

MJ Reasor, CL Ogle, PR Miles - Experimental lung research, 1990 - Taylor & Francis
Treatment of humans with the antiarrhythmic drug amiodarone can cause pulmonary
pathology and toxicity. The disorder is associated with the accumulation of phospholipid …

Artesunate inhibits renal ischemia reperfusion-stimulated lung inflammation in rats by activating HO-1 pathway

Z Liu, J Zhang, S Li, J Jiang - Inflammation, 2018 - Springer
ABSTRACT Artesunate (AS), a semi-synthetic derivative of Artemisia, has been shown to
exert a wide range of pharmacological effects, such as anti-inflammatory and antioxidant …

Amiodarone, unlike dronedarone, activates inflammasomes via its reactive metabolites: implications for amiodarone adverse reactions

R Kato, Y Ijiri, T Hayashi - Chemical research in toxicology, 2021 - ACS Publications
Amiodarone is a benzofuran derivative used to treat arrhythmias, but its use is limited by
adverse reactions. There is evidence that some of the severe adverse reactions such as liver …

Amiodarone-induced injury of human pulmonary artery endothelial cells: protection by alpha-tocopherol.

DL Kachel, TP Moyer, WJ Martin - Journal of Pharmacology and …, 1990 - ASPET
Amiodarone is a potent antidysrhythmic drug that is associated with severe pulmonary
toxicity. The mechanism of amiodarone pulmonary toxicity is poorly understood. To …

Comparison of oral, intranasal and aerosol administration of amiodarone in rats as a model of pulmonary phospholipidosis

A Patel, E Hoffman, D Ball, J Klapwijk, RT Steven… - Pharmaceutics, 2019 - mdpi.com
'Foamy'alveolar macrophages (FAM) observed in nonclinical toxicology studies during
inhaled drug development may indicate drug-induced phospholipidosis, but can also derive …

Astragaloside IV inhibits cigarette smoke-induced pulmonary inflammation in mice

Z Meiqian, Z Leying, C Chang - Inflammation, 2018 - Springer
The aim of this study was to investigate the effects of Astragaloside IV (AS) on cigarette
smoke (CS)-induced chronic obstructive pulmonary disease (COPD). Our results showed …

Magnesium isoglycyrrhizinate alleviates arsenic trioxide-induced cardiotoxicity: contribution of Nrf2 and TLR4/NF-κB signaling pathway

B Zheng, Y Yang, J Li, J Li, S Zuo, X Chu… - Drug Design …, 2021 - Taylor & Francis
Purpose Magnesium isoglycyrrhizinate (MgIG), a single stereoisomer magnesium salt of
glycyrrhizic acid, has beneficial effects on the cardiovascular system through anti …

Salbutamol inhibits lipopolysaccharide-induced inflammatory responses in rat peritoneal macrophages

S Tanaka, M Tsutsui, T Kishida, S Souma… - The Journal of …, 2010 - jstage.jst.go.jp
Acute and chronic inflammatory diseases are associated with the induction of inducible nitric
oxide synthase (iNOS) and inducible heme oxygenase (HO-1). These inducible enzymes …