Large-scale clinical validation of a lateral flow immunoassay for detection of cryptococcal antigen in serum and cerebrospinal fluid specimens

N Suwantarat, JB Dalton, R Lee, R Green… - … and infectious disease, 2015 - Elsevier
We compared a lateral flow immunoassay (LFA) to a currently used enzyme immunoassay
for detection of cryptococcal antigen in 396 sera and 651 cerebrospinal fluid specimens. We …

Point-of-care diagnosis and prognostication of cryptococcal meningitis with the cryptococcal antigen lateral flow assay on cerebrospinal fluid

T Kabanda, MJ Siedner, JD Klausner… - Clinical infectious …, 2014 - academic.oup.com
The cryptococcal antigen (CRAG) lateral flow assay (LFA) had 100% sensitivity and
specificity on cerebrospinal fluid samples. Pretreatment LFA titers correlated with …

Comparison of four assays for the detection of cryptococcal antigen

MJ Binnicker, DJ Jespersen, JE Bestrom… - Clinical and Vaccine …, 2012 - Am Soc Microbiol
We compared the performance of four assays for the detection of cryptococcal antigen in
serum samples (n= 634) and cerebrospinal fluid (CSF) samples (n= 51). Compared to latex …

Clinical utility of the cryptococcal antigen lateral flow assay in a diagnostic mycology laboratory

BJ McMullan, C Halliday, TC Sorrell, D Judd… - PLoS …, 2012 - journals.plos.org
Background Cryptococcus neoformans causes life-threatening meningitis. A recently
introduced lateral flow immunoassay (LFA) to detect cryptococcal antigen (CRAG) is …

Evaluation of a Cryptococcal antigen Lateral Flow Assay in serum and cerebrospinal fluid for rapid diagnosis of cryptococcosis in Colombia

DH Cáceres, A Zuluaga, ÁM Tabares… - Revista do Instituto de …, 2017 - SciELO Brasil
ABSTRACT A Lateral Flow Assay to detect cryptococcal antigen (CrAg® LFA) in serum and
cerebrospinal fluid for the rapid diagnosis of cryptococcosis was evaluated. A retrospective …

Evaluation of a new cryptococcal antigen lateral flow immunoassay in serum, cerebrospinal fluid and urine for the diagnosis of cryptococcosis: a meta-analysis and …

HR Huang, LC Fan, B Rajbanshi, JF Xu - PLoS One, 2015 - journals.plos.org
Background A new lateral flow immunoassay (LFA) for the detection of cryptococcal antigen
was developed. Objective We aimed to systematically review all relevant studies to evaluate …

Evaluation of a newly developed lateral flow immunoassay for the diagnosis of cryptococcosis

MD Lindsley, N Mekha, HC Baggett… - Clinical infectious …, 2011 - academic.oup.com
Background. Cryptococcosis is a common opportunistic infection of human
immunodeficiency virus (HIV)–infected individuals mostly occurring in resource-limited …

Evaluation of serum cryptococcal antigen testing using two novel semiquantitative lateral flow assays in persons with cryptococcal antigenemia

C Skipper, K Tadeo, E Martyn, E Nalintya… - Journal of clinical …, 2020 - Am Soc Microbiol
Early cryptococcal disease can be detected via circulating antigen in blood before fulminant
meningitis develops, when early antifungal therapy improves survival. Two semiquantitative …

Evaluation of a novel point-of-care lateral flow assay to detect cryptococcal antigen in plasma and CSF

M Rolfes, E Butler, H Nabeta, R Kwizera, D Meya… - 2012 - nru.uncst.go.ug
Current diagnostics for Cryptococcal meningitis (CM) rely on India ink, CSF culture, or
cryptococcal antigen (CRAG) latex agglutination test. India ink is relatively insensitive …

The cryptococcal antigen lateral flow assay: A point-of-care diagnostic at an opportune time

MW Tang, KV Clemons, DA Katzenstein… - Critical reviews in …, 2016 - Taylor & Francis
Cryptococcal meningitis is a devastating HIV-related opportunistic infection, affecting nearly
1 million individuals and causing over 500 000 deaths each year. The burden of disease is …