Objective Myeloid cells, including macrophages and dendritic cells, are a prominent
component of central nervous system (CNS) infiltrates during multiple sclerosis (MS) and the …

Multiple sclerosis (MS) is a debilitating neurological disorder of the central nervous system
(CNS), characterized by activation and infiltration of leukocytes and dendritic cells into the …

Multiple sclerosis (MS) is a chronic autoimmune disease that affects the myelination of the
neurons present in the central nervous system (CNS). The exact etiology of MS development …

Inflammation is a series of processes designed for eventual clearance of pathogens and
repair of damaged tissue. In the context of autoimmune recognition, inflammatory processes …

Specialized populations of tissue-resident myeloid cells inhabit every organ of the body.
While many of these populations appear similar morphologically and phenotypically, they …

Microglial cells are central nervous system (CNS) resident cells that are thought to become
activated and contribute to the inflammation that occurs in the human autoimmune disease …

In both multiple sclerosis and its model experimental autoimmune encephalomyelitis (EAE),
the extent of resident microglia activation and infiltration of monocyte-derived cells to the …

In the human disorder multiple sclerosis (MS) and in the model experimental autoimmune
encephalomyelitis (EAE), macrophages predominate in demyelinated areas and their …

Multiple sclerosis (MS) is characterized by pathological inflammation that results from the
recruitment of lymphoid and myeloid immune cells from the blood into the brain. Due to …

Discussions of multiple sclerosis (MS) pathophysiology tend to focus on T cells and B cells
of the adaptive immune response. The innate immune system is less commonly considered …