In the brain, microglia continuously scan the surrounding extracellular space in order to
respond to damage or infection by becoming activated and participating in …

Background Immune mechanisms have been implicated in the pathogenesis of depression.
Translocator protein (TSPO)–targeted positron emission tomography (PET) has been used …

Prior studies indicated that neuroinflammation might play a role in the pathophysiology of
major depressive disorder (MDD). The purpose of this study was to examine changes in a …

Abstract The use of Translocator Protein 18 kDa (TSPO) as a clinical neuroimaging
biomarker of brain injury and neuroinflammation has increased exponentially in the last …

ABSTRACT BACKGROUND Immune mechanisms have been implicated in the
pathogenesis of depression, and translocator-protein (TSPO) targeted positron emission …

Introduction Post‐traumatic stress disorder (PTSD) is an anxiety disorder induced by
psychologically traumatic events. Using a rat model, this study aimed to determine whether …

The notion that inflammation and immune signals may play a role in the pathophysiology of
psychiatric conditions has been gaining considerable support. In no small part, this support …

Background Posttraumatic stress disorder (PTSD) is associated with an enhanced risk for
cardiovascular and other inflammatory diseases. Chronic low-level inflammation has been …

Several neurological and psychiatric disorders have been associated with
neuroinflammation, defined by the activation of microglia and astrocytes in the brain. PET …

Background: γ-Aminobutyric acidergic (GABAergic) dysfunction and immune activation have
been implicated in the pathophysiology of schizophrenia. Preclinical evidence suggests that …