A chlamydial plasmid-dependent secretion system for the delivery of virulence factors to the host cytosol

L Lei, C Yang, MJ Patton, M Smelkinson, D Dorward… - MBio, 2021 - Am Soc Microbiol
Chlamydia are obligate intracellular Gram-negative bacteria distinguished by a unique
developmental biology confined within a parasitophorous vacuole termed an inclusion. The …

Plasmid-mediated transformation tropism of chlamydial biovars

L Song, JH Carlson, B Zhou, K Virtaneva… - Pathogens and …, 2014 - academic.oup.com
Chlamydia trachomatis and C. muridarum are human and mouse pathogens, respectively,
which show high conservation of gene order and content. Both species contain a common …

Chlamydia trachomatis plasmid-encoded Pgp4 is a transcriptional regulator of virulence-associated genes

L Song, JH Carlson, WM Whitmire, L Kari… - Infection and …, 2013 - Am Soc Microbiol
Chlamydia trachomatis causes chronic inflammatory diseases of the eye and genital tract
and has global medical importance. The chlamydial plasmid plays an important role in the …

Chlamydial lytic exit from host cells is plasmid regulated

C Yang, T Starr, L Song, JH Carlson, GL Sturdevant… - MBio, 2015 - Am Soc Microbiol
Chlamydia trachomatis is an obligate intracellular bacterium that is a globally important
human pathogen. The chlamydial plasmid is an attenuating virulence factor, but the …

Orchestration of the mammalian host cell glucose transporter proteins-1 and 3 by Chlamydia contributes to intracellular growth and infectivity

X Wang, K Hybiske, RS Stephens - Pathogens and Disease, 2017 - academic.oup.com
Chlamydia are gram-negative obligate intracellular bacteria that replicate within a discrete
cellular vacuole, called an inclusion. Although it is known that Chlamydia require essential …

Type III secretion in Chlamydia

EA Rucks - Microbiology and Molecular Biology Reviews, 2023 - Am Soc Microbiol
Type III secretion systems (T3SSs) are utilized by Gram-negative pathogens to enhance
their pathogenesis. This secretion system is associated with the delivery of effectors through …

The Chlamydial Plasmid-Encoded Protein pgp3 Is Secreted into the Cytosol of Chlamydia-Infected Cells

Z Li, D Chen, Y Zhong, S Wang, G Zhong - Infection and immunity, 2008 - Am Soc Microbiol
The chlamydial cryptic plasmid encodes eight putative open reading frames (ORFs),
designated pORF1 to-8. Antibodies raised against these ORF proteins were used to localize …

Requirement of GrgA for Chlamydia infectious progeny production, optimal growth, and efficient plasmid maintenance

B Lu, Y Wang, W Wurihan, A Cheng, S Yeung… - Mbio, 2024 - Am Soc Microbiol
Chlamydia, an obligate intracellular bacterial pathogen, has a unique developmental cycle
involving the differentiation of invading elementary bodies (EBs) to noninfectious reticulate …

Chlamydial plasmid-dependent pathogenicity

G Zhong - Trends in microbiology, 2017 - cell.com
Most Chlamydia species carry a 7.5 kb plasmid encoding eight open reading frames
conventionally called plasmid glycoproteins 1–8 or pGP1–8. Although the plasmid is not …

Chlamydia trachomatis plasmid gene protein 3 is essential for the establishment of persistent infection and associated immunopathology

C Yang, L Kari, L Lei, JH Carlson, L Ma, CE Couch… - MBio, 2020 - Am Soc Microbiol
Chlamydia trachomatis is an obligate intracellular bacterial pathogen that causes blinding
trachoma and sexually transmitted disease afflicting hundreds of millions of people globally …