Understanding CD8+ T cell responses generated by live virus vectors is critical for the
rational design of next generation HIV CTL-based vaccines. We used recombinant influenza …

The H-2D b-restricted CD8 T cell immune response to influenza A is directed at two well-
described epitopes, nucleoprotein 366 (NP366) and acid polymerase 224 (PA224). The …

A reverse genetics strategy was used to insert the OVA peptide (amino acid sequence
SIINFEKL; OVA 257–264) into the neuraminidase stalk of both the A/PR8 (H1N1) and A/HK× …

TCR repertoire diversity can influence the efficacy of CD8+ T‐cell populations, with greater
breadth eliciting better protection. We analyzed TCRβ diversity and functional capacity for …

Little is known about the mechanisms governing TCR repertoire selection in response to
foreign antigens. Here, we evaluate the molecular features of the murine C57BL/6 (B6) TCR …

During acute human viral infections, such as influenza A, specific cytotoxic T lymphocytes
(CTL) are generated which aid virus clearance. We have observed that in HLA-A* 0201+ …

Influenza primed mice are protected against lethal infection with H1N1 A/CA/04/E3/09 virus,
and T depletion and serum transfer studies suggest a T-dependent mechanism. We …

The CD8+ T cell response is important in the control of many viral and other infections.
There have been many studies aimed at better understanding the influence of T cell receptor …

Early studies of influenza virus-specific CD8+ T cell-mediated immunity indicated that the
level of CTL activity associated with H2D b is greatly diminished in mice that also express …

Abstract Influenza A, B and C viruses (IAV, IBV and ICV, respectively) circulate globally and
infect humans, with IAV and IBV causing the most severe disease. CD8+ T cells confer cross …