[HTML][HTML] Sepsis—pathophysiology and therapeutic concepts

D Jarczak, S Kluge, A Nierhaus - Frontiers in medicine, 2021 - frontiersin.org
Sepsis is a life-threatening condition and a global disease burden. Today, the
heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated …

The immunopathology of sepsis and potential therapeutic targets

T van der Poll, FL van de Veerdonk… - Nature Reviews …, 2017 - nature.com
Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. In sepsis, the immune response that is initiated by an invading …

Inflammation and cell death of the innate and adaptive immune system during sepsis

C Nedeva - Biomolecules, 2021 - mdpi.com
Sepsis is a life-threatening medical condition that occurs when the host has an uncontrolled
or abnormal immune response to overwhelming infection. It is now widely accepted that …

Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy

RS Hotchkiss, G Monneret, D Payen - Nature Reviews Immunology, 2013 - nature.com
Sepsis—which is a severe life-threatening infection with organ dysfunction—initiates a
complex interplay of host pro-inflammatory and anti-inflammatory processes. Sepsis can be …

The immunology of sepsis

T van der Poll, M Shankar-Hari, WJ Wiersinga - Immunity, 2021 - cell.com
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection. This recently implemented definition does not capture the …

Immune dysregulation in sepsis: experiences, lessons and perspectives

M Cao, G Wang, J Xie - Cell Death Discovery, 2023 - nature.com
Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host
responses to infection. Not only does sepsis pose a serious hazard to human health, but it …

[HTML][HTML] Immunopathophysiology of human sepsis

WJ Wiersinga, T van der Poll - EBioMedicine, 2022 - thelancet.com
Sepsis is an ill-defined syndrome yet is a leading cause of morbidity and mortality
worldwide. The most recent consensus defines sepsis as life-threatening organ dysfunction …

Sepsis: rethinking the approach to clinical research

JC Marshall - Journal of Leucocyte Biology, 2008 - academic.oup.com
The clinical syndrome of sepsis encompasses a highly heterogeneous group of clinical
disorders, varying with respect to the site, bacteriology, and even presence of infection and …

Signaling pathways and intervention therapies in sepsis

Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

Sepsis and nosocomial infection: patient characteristics, mechanisms, and modulation

SJ Denstaedt, BH Singer, TJ Standiford - Frontiers in Immunology, 2018 - frontiersin.org
Sepsis is a leading cause of death worldwide. After initial trials modulating the
hyperinflammatory phase of sepsis failed, generations of researchers have focused on …