The skeleton is a common site of cancer metastasis and malignancy with the resultant
lesions often being incurable. Interactions between metastatic cancer cells and the bone …

Skeletal metastasis is a serious complication of many primary cancers. A common feature of
tumor cells that metastasize to the bone marrow microenvironment is that they initiate a …

Bone metastasis is the most advanced stage of many cancers and indicates a poor
prognosis for patients due to resistance to anti-tumor therapies. The establishment of …

Tumor‐induced bone disease is a dynamic process that involves interactions with many cell
types. Once metastatic cancer cells reach the bone, they are in contact with many different …

The tumor microenvironment is comprised of diverse stromal cell populations in addition to
tumor cells. Increasing evidence now clearly supports the role of microenvironment stromal …

The dissemination of cancer from the primary site of growth to distant organs is an early
event that leads to the random deposition of tumor cells throughout the organs of the body …

Metastatic bone disease is a complex condition resulting from the migration and colonization
of cancer cells from their primary site to the bone microenvironment, where they typically …

The skeleton is a common site for cancer metastases with the bone microenvironment
providing the appropriate conditions for cancer cell colonization. Once in bone, cancer cells …

Tumor mass is constituted by a heterogeneous group of cells, among which a key role is
played by the cancer stem cells (CSCs), possessing high regenerative properties. CSCs …

Bone serves one of the most congenial metastatic microenvironments for multiple types of
solid tumors, but its role in this process remains under-explored. Among many cell …