Abstract Purpose of Review An important number of newly identified molecular alterations in
prostate cancer affect gene encoding master regulators of chromatin biology epigenetic …

Simple Summary Chromatin and epigenetic alterations in cancer are responsible for a wide
range of transcriptional changes that link DNA mutations to tumor phenotype. In this review …

Epigenetic alterations, including changes in DNA methylation, histone modifications and
nucleosome remodeling, result in abnormal gene expression patterns that contribute to …

Tumor evolution is based on the ability to constantly mutate and activate different pathways
under the selective pressure of targeted therapies. Epigenetic alterations including those of …

Epigenetic mechanisms, including histone modifications, nucleosomal remodeling and
chromosomal looping, contribute to the onset and progression of prostate cancer. Recent …

Epigenetics is the main mechanism that controls transcription of specific genes with no
changes in the underlying DNA sequences. Epigenetic alterations lead to abnormal gene …

The initiation of prostate cancer has been long associated with DNA copy-number
alterations, the loss of specific chromosomal regions and gene fusions, and driver mutations …

Highlights•Patients who receive antiandrogen treatments are more likely to develop
CRPC.•A genomic landscape study has identified aberrant epigenetic events in CRPC and …

Prostate cancer is one of the most frequent cancers in males in Western industrialized
countries. Its course is highly variable, from indolent to highly lethal. Genetic changes vary …

The androgen receptor (AR) is commonly known as a key transcription factor in prostate
cancer development, progression and therapy resistance. Genome-wide chromatin …