The limited number of in vivo germ cells poses an impediment to genome-wide studies.
Here, we applied a small-scale chromatin immunoprecipitation sequencing (ChIP-seq) …

Background Germline stem cells play an essential role in establishing the fertility of an
organism. Although extensively characterized, the regulatory mechanisms that govern the …

Chromatin remodeling is important for the epigenetic reprogramming of human primordial
germ cells. However, the comprehensive chromatin state has not yet been analyzed for …

Proper development of fetal germ cells (FGCs) is vital for the precise transmission of genetic
and epigenetic information through generations. The transcriptional landscapes of human …

In contrast to mouse, human female germ cells develop asynchronously. Germ cells
transition to meiosis, erase genomic imprints, and reactivate the X chromosome. It is …

Human adult spermatogenesis balances spermatogonial stem cell (SSC) self-renewal and
differentiation, alongside complex germ cell-niche interactions, to ensure long-term fertility …

Germ cell specification is accompanied by epigenetic remodeling, the scale and specificity
of which are unclear. Here, we quantitatively delineate chromatin dynamics during induction …

Germline cells are the beginning of new individuals in multicellular animals, including
humans. Our understanding of these cell types is limited by the difficulty of analyzing the …

Germline development varies significantly across metazoans. However, mammalian
primordial germ cell (PGC) development has key conserved landmarks, including a critical …

Mammalian male germ cell development is a stepwise cell-fate transition process; however,
the full-term developmental profile of male germ cells remains undefined. Here, by …