Fabrication of Nanocrystals for Enhanced Distribution of a Fatty Acid Synthase Inhibitor (Orlistat) as a Promising Method to Relieve Solid Ehrlich Carcinoma-Induced …
JA Alamoudi, TA El-Masry, M Nasr, IT Ibrahim… - Pharmaceuticals, 2024 - mdpi.com
Background: Orlistat (ORL) is an effective irreversible inhibitor of the lipase enzyme, and it
possesses anticancer effects and limited aqueous solubility. This study was designed to …
possesses anticancer effects and limited aqueous solubility. This study was designed to …
[HTML][HTML] Therapeutic efficiency of Tamoxifen/Orlistat nanocrystals against solid ehrlich carcinoma via targeting TXNIP/HIF1-α/MMP-9/P27 and BAX/Bcl2/P53 signaling …
TA El-Masry, MMF El-Nagar, GA Oriquat… - Biomedicine & …, 2024 - Elsevier
Abstract Background Orlistat (Orli) is an anti-obesity medication that has been approved by
the US Food and Drug Administration. It has relatively limited oral bioavailability with …
the US Food and Drug Administration. It has relatively limited oral bioavailability with …
Development of a self-assembled nanoparticle formulation of orlistat, nano-ORL, with increased cytotoxicity against human tumor cell lines
Fatty acid synthase (FASN), the enzyme that catalyzes de novo synthesis of fatty acids, is
expressed in many cancer types. Its potential as a therapeutic target is well recognized, but …
expressed in many cancer types. Its potential as a therapeutic target is well recognized, but …
Novel orlistat LDL-like nanoparticles as potential anti-cancer medicines
G Bebawy - 2022 - eprints.nottingham.ac.uk
Objectives: The field of Nano-therapeutics has gained vast attention over the past decades,
described as the future cancer medicine. Controlling the particle size is highly crucial for …
described as the future cancer medicine. Controlling the particle size is highly crucial for …
Pharmacokinetic and pharmacodynamic evaluation of resveratrol loaded cationic liposomes for targeting hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death
worldwide. The destructive nature of the disease makes it difficult for clinicians to manage …
worldwide. The destructive nature of the disease makes it difficult for clinicians to manage …
[HTML][HTML] Nano lipidic carriers for codelivery of sorafenib and ganoderic acid for enhanced synergistic antitumor efficacy against hepatocellular carcinoma
B Wang, L Sun, M Wen, Y Tan, WH Almalki… - Saudi Pharmaceutical …, 2021 - Elsevier
The current study focuses on the development and evaluation of nano lipidic carriers (NLCs)
for codelivery of sorafenib (SRF) and ganoderic acid (GA) therapy in order to treat …
for codelivery of sorafenib (SRF) and ganoderic acid (GA) therapy in order to treat …
Entrapment of an EGFR inhibitor into nanostructured lipid carriers (NLC) improves its antitumor activity against human hepatocarcinoma cells
ML Bondì, A Azzolina, EF Craparo, C Botto… - Journal of …, 2014 - Springer
Background In hepatocellular carcinoma (HCC), different signaling pathways are de-
regulated, and among them, the expression of the epidermal growth factor receptor (EGFR) …
regulated, and among them, the expression of the epidermal growth factor receptor (EGFR) …
[HTML][HTML] 4-Hexylresorcinol Loaded Solid Lipid Nanoparticles for Enhancing Anticancer Activity
S Yeo, S Jung, H Kim, JH Ahn, SJ Hwang - Pharmaceuticals, 2024 - mdpi.com
Background: Cancer is one of the most significant threats to human health. Following
surgical excision, chemotherapy is an effective strategy against remaining cancer cells. 4 …
surgical excision, chemotherapy is an effective strategy against remaining cancer cells. 4 …
Intracellular uptake of etoposide-loaded solid lipid nanoparticles induces an enhancing inhibitory effect on gastric cancer through mitochondria-mediated apoptosis …
The objective of this study was to prepare and characterize etoposide (VP16)-loaded solid
lipid nanoparticles (SLNs) and evaluate their antitumor activity in vitro. VP16-SLNs were …
lipid nanoparticles (SLNs) and evaluate their antitumor activity in vitro. VP16-SLNs were …
The Effect of Nano-Encapsulated Orlistat on Prostate Cancer: An In vitro Study
F Armutcu, B Adam - Journal of Nanotechnology and …, 2024 - scientificarchives.com
Background: The targeted inhibition of fatty acid synthase (FASN) by Orlistat, a potent FASN
inhibitor, has been shown to block tumor proliferation and induce apoptosis in cultured …
inhibitor, has been shown to block tumor proliferation and induce apoptosis in cultured …