Selective antagonism of capsaicin by capsazepine : evidence for a spinal receptor site in
capsaicin-induced antinociception | CiNii Research CiNii 国立情報学研究所 学術情報 …

1 Capsazepine has recently been described as a competitive capsaicin antagonist. We have
used this compound to test the hypotheses that the in vitro and in vivo effects of capsaicin …

This study was designed to investigate the antinociceptive activity of capsaicin in acute and
persistent nocifensor behavioural models and to determine whether this was mediated via a …

1. Intravenous infusion of capsazocaine (CAPBZ), a molecular fusion product of irritant
synthetic capsaicin and local analgesic benzocaine, at 100 micrograms/kg/min for 15 min …

We have studied the effects of capsaicin, administered at concentrations found to be
antinociceptive in behavioural tests, on nociceptive responses evoked both in spinal dorsal …

Capsaicin activates poorly myelinated primary afferent neurons, many of which are
polymodal nociceptors. Activation is accompanied by membrane depolarization and the …

Intraplantar injection of capsaicin (1.6 μg/paw) into the mouse hindpaw produced an acute
paw-licking/biting response. This study was designed (1) to investigate the antinociceptive …

We have studied the effect of NE 19550 (olvanil, N-(4-hydroxy-3-methoxyphenyl) methyl-9Z-
octadecenamide), a capsaicin analogue with approximately equipotent antinociceptive …

Capsaicin was tested on peripheral fibres in vitro to determine whether evoked
depolarization or desensitization were likely to explain the antinociception observed after …

The relationship of capsaicin desensitization to the antinociception produced by acute
capsaicin administration was studied in the rat. Cutaneous application of 1% capsaicin …