The retinoblastoma protein (pFl6) plays an important role in the control of cell proliferation,
apparently by binding to and regulating cellular transcription factors such as E2F. Here we …

Loss of a functional retinoblastoma tumor suppressor gene product, pRB, is a key step in the
development of many human tumors. pRB is a negative regulator of cell proliferation and …

Studies of naturally occurring mutations of the RB1 tumor suppressor gene have indicated
that the E1A/T antigen-binding domain is important for pRb function. Mutations engineered …

The E2F transcription factors play a role in regulating the expression of genes required for
cell proliferation. Their activity appears to be regulated by association with the …

The activity of the E2F transcription factor is controlled by physical association with the
retinoblastoma protein (pRB) and two related proteins, p107 and p130. The pRB family …

The retinoblastoma gene product, pRB, regulates cell proliferation by binding to and
inhibiting the activity of key growth promoting proteins. Several cellular proteins have been …

Although it is generally believed that the product of the retinoblastoma susceptibility gene
(RB7) is an important regulator of cell proliferation, the biochemical mechanism for its action …

Much has been written about the functions of the E2F transcription factor and the product of
the retinoblastoma tumor suppressor gene (pRB). These proteins have been described in …

The E2F family of transcription factors are downstream effectors of the retinoblastoma
protein, pRB, pathway and are essential for the timely regulation of genes necessary for cell …

The E2F transcription factor has been implicated in the regulation of genes whose products
are involved in cell proliferation. Two proteins have recently been identified with E2F-like …