The genital tract virulence factor pGP3 is essential for Chlamydia muridarum colonization in the gastrointestinal tract

L Shao, T Zhang, J Melero, Y Huang, Y Liu… - Infection and …, 2018 - Am Soc Microbiol
The cryptic plasmid is essential for Chlamydia muridarum dissemination from the genital
tract to the gastrointestinal (GI) tract. Following intravaginal inoculation, a C. muridarum …

The Plasmid-Encoded pGP3 Promotes Chlamydia Evasion of Acidic Barriers in Both Stomach and Vagina

T Zhang, Z Huo, J Ma, C He, G Zhong - Infection and immunity, 2019 - Am Soc Microbiol
Although Chlamydia trachomatis is a human genital tract pathogen, chlamydial organisms
have frequently been detected in both vaginal and rectal swab samples of animals and …

Distinct roles of chromosome-versus plasmid-encoded genital tract virulence factors in promoting Chlamydia muridarum colonization in the gastrointestinal tract

JJ Koprivsek, T Zhang, Q Tian, Y He, H Xu… - Infection and …, 2019 - Am Soc Microbiol
The genital pathogen Chlamydia is known to colonize the gastrointestinal tract. Orally
delivered Chlamydia muridarum can reach the colon and maintain a long-lasting …

Plasmid-encoded Pgp3 is a major virulence factor for Chlamydia muridarum to induce hydrosalpinx in mice

Y Liu, Y Huang, Z Yang, Y Sun, S Gong… - Infection and …, 2014 - Am Soc Microbiol
Hydrosalpinx induction in mice by Chlamydia muridarum infection, a model that has been
used to study C. trachomatis pathogenesis in women, is known to depend on the cryptic …

Plasmid-Encoded Pgp5 Is a Significant Contributor to Chlamydia muridarum Induction of Hydrosalpinx

Y Huang, Q Zhang, Z Yang, T Conrad, Y Liu, G Zhong - PloS one, 2015 - journals.plos.org
We have previously shown that the plasmid-encoded Pgp3 is a major virulence factor for C.
muridarum induction of hydrosalpinx. We now report that Pgp5 also plays a significant role …

Chlamydial plasmid-dependent pathogenicity

G Zhong - Trends in microbiology, 2017 - cell.com
Most Chlamydia species carry a 7.5 kb plasmid encoding eight open reading frames
conventionally called plasmid glycoproteins 1–8 or pGP1–8. Although the plasmid is not …

Chlamydia Deficient in Plasmid-Encoded pGP3 Is Prevented from Spreading to Large Intestine

Z Huo, C He, Y Xu, T Jia, J Wang… - Infection and …, 2020 - Am Soc Microbiol
The cryptic plasmid pCM is critical for chlamydial colonization in the gastrointestinal tract.
Nevertheless, orally inoculated plasmid-free Chlamydia sp. was still able to colonize the gut …

The cryptic plasmid is more important for Chlamydia muridarum to colonize the mouse gastrointestinal tract than to infect the genital tract

L Shao, J Melero, N Zhang, B Arulanandam… - PLoS …, 2017 - journals.plos.org
Chlamydia has been detected in the gastrointestinal tracts of both animals and humans.
However, the mechanism by which Chlamydia colonizes the gut remains unclear …

Chlamydia overcomes multiple gastrointestinal barriers to achieve long-lasting colonization

G Zhong - Trends in microbiology, 2021 - cell.com
Chlamydia trachomatis (CT) is frequently detected in the human gastrointestinal (GI) tract
despite its leading role in sexually transmitted bacterial infections in the genital tract …

Chlamydia muridarum with Mutations in Chromosomal Genes tc0237 and/or tc0668 Is Deficient in Colonizing the Mouse Gastrointestinal Tract

L Shao, T Zhang, Q Liu, J Wang, G Zhong - Infection and immunity, 2017 - Am Soc Microbiol
Chlamydiae colonize the gastrointestinal tracts of both animals and humans. However, their
medical significance remains unknown. We have previously shown that wild-type Chlamydia …