Chlamydia trachomatis contains a conserved∼ 7.5-kb plasmid. Loss of the plasmid results
in reduced glycogen accumulation, failure to activate TLR2, and reduced infectivity. We …

Intravaginal infection with plasmid-competent but not plasmid-free Chlamydia muridarum
induces hydrosalpinx in mouse upper genital tract, indicating a critical role of the plasmid in …

We hypothesized that the plasmid of urogenital isolates of Chlamydia trachomatis would
modulate infectivity and virulence in a mouse model. To test this hypothesis, we infected …

Chlamydia is known to both ascend to the upper genital tract and spread to the
gastrointestinal tract following intravaginal inoculation. Gastrointestinal Chlamydia was …

Chlamydia psittaci is the etiological agent of chlamydiosis in birds and can be transmitted to
humans, causing severe systemic disease. C. psittaci infects a broad range of hosts; strains …

Chlamydia in the genital tract is known to spread via the blood circulation system to the large
intestine lumen to achieve long-lasting colonization. However, the precise pathways by …

Chlamydia trachomatis is an obligate intracellular mucosotropic pathogen of significant
medical importance. It is the etiological agent of blinding trachoma and bacterial sexually …

Functional genetic analysis of Chlamydia has been a challenge due to the historical genetic
intractability of Chlamydia, although recent advances in chlamydial genetic manipulation …

Chlamydia has been detected in the gastrointestinal tracts of both animals and humans.
However, it remains unclear whether the chlamydial organisms can be introduced into the …

Although Chlamydia-induced hydrosalpinx in women and mice has been used as a
surrogate marker for tubal infertility, the medical relevance of nontubal pathologies, such as …