Manipulation of ACE2 expression in COVID-19

F Chaudhry, S Lavandero, X Xie, B Sabharwal… - Open …, 2020 - openheart.bmj.com
SARS-CoV-2 is the virus responsible for the ongoing COVID-19 outbreak. The virus uses
ACE2 receptor for viral entry. ACE2 is part of the counter-regulatory renin-angiotensin …

[HTML][HTML] ACE2, much more than just a receptor for SARS-COV-2

L Samavati, BD Uhal - Frontiers in cellular and infection microbiology, 2020 - frontiersin.org
The rapidly evolving pandemic of severe acute respiratory syndrome coronavirus (SARS-
CoV-2) infection worldwide cost many lives. The angiotensin converting enzyme-2 (ACE-2) …

[HTML][HTML] ACE2 as a therapeutic target for COVID-19; its role in infectious processes and regulation by modulators of the RAAS system

V Michaud, M Deodhar, M Arwood… - Journal of Clinical …, 2020 - mdpi.com
Angiotensin converting enzyme 2 (ACE2) is the recognized host cell receptor responsible for
mediating infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Expression of ACE2, the SARS-CoV-2 receptor, in lung tissue of patients with type 2 diabetes

SRA Wijnant, M Jacobs, HP Van Eeckhoutte… - Diabetes, 2020 - Am Diabetes Assoc
Increased expression of pulmonary ACE2, the SARS-CoV-2 receptor, could contribute to
increased infectivity of COVID-19 in patients with diabetes, but ACE2 expression has not …

Should ACE2 be given a chance in COVID-19 therapeutics: A semi-systematic review of strategies enhancing ACE2

U Kaur, K Acharya, R Mondal, A Singh, L Saso… - European journal of …, 2020 - Elsevier
The severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) has resulted in almost
28 million cases of COVID-19 (Corona virus disease-2019) and more than 900000 deaths …

[HTML][HTML] ACE2: the major cell entry receptor for SARS-CoV-2

F Scialo, A Daniele, F Amato, L Pastore, MG Matera… - Lung, 2020 - Springer
Despite the unprecedented effort of the scientific community, the novel SARS-CoV-2 virus
has infected more than 46 million people worldwide, killing over one million two hundred …

[HTML][HTML] Angiotensin-converting enzyme 2 expression and severity of SARS-CoV-2 infection

S Alabsi, A Dhole, S Hozayen, SA Chapman - Microorganisms, 2023 - mdpi.com
Angiotensin-converting enzyme 2 (ACE2), first discovered in 2000, serves as an important
counterregulatory enzyme to the angiotensin II-mediated vasoconstrictive, pro-inflammatory …

ACE2 and COVID-19 and the resulting ARDS

X Zhang, S Li, S Niu - Postgraduate medical journal, 2020 - academic.oup.com
This article reviews the correlation between ACE2 and COVID-19 and the resulting acute
respiratory distress syndrome (ARDS). ACE2 is a crucial component of the renin-angiotensin …

[HTML][HTML] A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection

C Blume, CL Jackson, CM Spalluto, J Legebeke… - Nature …, 2021 - nature.com
Abstract Angiotensin-converting enzyme 2 (ACE2) is the main entry point in airway epithelial
cells for SARS-CoV-2. ACE2 binding to the SARS-CoV-2 protein spike triggers viral fusion …

[HTML][HTML] ACE2 in the era of SARS-CoV-2: controversies and novel perspectives

F Saponaro, G Rutigliano, S Sestito… - Frontiers in Molecular …, 2020 - frontiersin.org
Angiotensin-converting enzyme 2 (ACE2) is related to ACE but turned out to counteract
several pathophysiological actions of ACE. ACE2 exerts antihypertensive and …