A systematic review of magnesium sulfate for perinatal neuroprotection: what have we learnt from the past decade?

R Galinsky, JM Dean, I Lingam, NJ Robertson… - Frontiers in …, 2020 - frontiersin.org
There is an important unmet need to improve long term outcomes of encephalopathy for
preterm and term infants. Meta-analyses of large controlled trials suggest that maternal …

Magnesium sulphate and perinatal mortality and morbidity in very-low-birthweight infants born between 24 and 32 weeks of gestation in Japan

M Ohhashi, T Yoshitomi, K Sumiyoshi… - European Journal of …, 2016 - Elsevier
Objective Maternal exposure to magnesium sulphate has a neuroprotective effect in
premature infants. This study aimed to examine this neuroprotective effect and the dose …

Magnesium sulphate for fetal neuroprotection: benefits and challenges of a systematic knowledge translation project in Canada

KC Teela, DA De Silva, K Chapman, AR Synnes… - BMC Pregnancy and …, 2015 - Springer
Background Administration of magnesium sulphate (MgSO 4) to women with imminent
preterm birth at< 34 weeks is an evidence-based antenatal neuroprotective strategy to …

Neonatal serum magnesium concentrations are determined by total maternal dose of magnesium sulfate administered for neuroprotection

P Borja-Del-Rosario, SK Basu, S Haberman… - Journal of Perinatal …, 2014 - degruyter.com
Background: Antenatal magnesium in preterm labor for neuroprotection decreases the
incidence of cerebral palsy. However, there are no guidelines on the dose and duration of …

Antenatal magnesium sulphate and adverse neonatal outcomes: A systematic review and meta-analysis

E Shepherd, RA Salam, D Manhas, A Synnes… - PLoS …, 2019 - journals.plos.org
Background There is widespread, increasing use of magnesium sulphate in obstetric
practice for pre-eclampsia, eclampsia, and preterm fetal neuroprotection; benefit for …

Magnesium as a neuroprotective agent: a review of its use in the fetus, term infant with neonatal encephalopathy, and the adult stroke patient

I Lingam, NJ Robertson - Developmental neuroscience, 2018 - karger.com
Magnesium is an intracellular cation essential for many en-zymatic processes and cellular
functions. Magnesium sulfate acts as an endogenous calcium channel antagonist at …

Implementation of a clinical practice guideline for antenatal magnesium sulphate for neuroprotection in A ustralia and N ew Z ealand

E Bain, T Bubner, P Ashwood… - Australian and New …, 2013 - Wiley Online Library
Health professionals at 25 A ustralian and N ew Z ealand tertiary maternity hospitals were
surveyed about local implementation of a clinical practice guideline for antenatal …

Magnesium sulfate and novel therapies to promote neuroprotection

RA Jameson, HB Bernstein - Clinics in perinatology, 2019 - perinatology.theclinics.com
Preterm delivery (PTD) is a major cause of neonatal morbidity and mortality, with surviving
infants at risk for long-term neurologic sequelae. Although any birth occurring before the …

School-age outcomes following a randomized controlled trial of magnesium sulfate for neuroprotection of preterm infants

C Chollat, M Enser, E Houivet, D Provost… - The journal of …, 2014 - Elsevier
In a French randomized trial, children at school-age demonstrated no evidence of harm from
fetal exposure to MgSO 4 before very preterm birth. Motor dysfunction/death, qualitative …

Magnesium sulfate therapy for the prevention of cerebral palsy in preterm infants: a decision-analytic and economic analysis

AG Cahill, AO Odibo, MJ Stout, WA Grobman… - American journal of …, 2011 - Elsevier
OBJECTIVE: We sought to estimate the cost-effectiveness of magnesium neuroprophylaxis
for all women at risk for preterm birth< 32 weeks. STUDY DESIGN: A decision analytic and …