Uneven oxygen supply in solid tumors leads to hypoxic and normoxic regions. Hypoxic cells
exhibit increased secretion of lactate, which creates an acidic tumor microenvironment …

Tumors harbor diverse compartments of cells with distinct metabolic properties and
phenotypes, but the mechanism by which metabolic commensalism among distinct subsets …

Human mesenchymal stem cells (hMSCs) are bone marrow-derived stromal cells, which
play a role in tumor progression. We have shown earlier that breast cancer cells secrete …

Tumor heterogeneity is an important feature of malignant tumors, and cell subpopulations
may positively interact to facilitate tumor progression. Studies have shown that hypoxic …

Lactate acidosis is often observed in the tumor microenvironment (TME) of solid tumors. This
is because glucose breaks down quickly via glycolysis, causing lactate acidity. Lactate is …

Reprogramming energy metabolism, such as enhanced glycolysis, is an Achilles' heel in
cancer treatment. Most studies have been performed on isolated cancer cells. Here, we …

Tumor evolution is influenced by events involving tumor cells and the environment in which
they live, known as the tumor microenvironment (TME). TME is a functional and structural …

Background/Aim: Hypoxia promotes tumor proliferation and metastasis in colorectal cancer
(CRC). Since the tumor microenvironment is generally characterized by hypoxia, its …

Purpose Hypoxia has been found to play an important role in regulating the biological
characteristics of cancer stem cells (cCSCs). In this study, we tested whether a tumor …

It is well known that solid hypoxic tumour cells oxidise glucose through glycolysis, and the
end product of this pathway is fermented into lactate which accumulates in the tumour …