Tumor hypoxia induces epithelial-mesenchymal transition (EMT), which induces invasion
and metastasis, and is linked to cancer stem cells (CSCs). Whether EMT generates CSCs de …

Normal cells mainly rely on oxidative phosphorylation as an effective energy source in the
presence of oxygen. In contrast, most cancer cells use less efficient glycolysis to produce …

Abstract Background Tumor endothelial cells (TECs) perform tumor angiogenesis, which is
essential for tumor growth and metastasis. Tumor cells produce large amounts of lactic acid …

Cancer cells can adapt to low energy sources in the face of ATP depletion as well as to their
high levels of ROS by altering their metabolism and energy production networks which might …

In sporadic colon cancer, colon cancer stem cells (CCSCs) initiate tumorigenesis and may
contribute to late disease recurrences and metastases. We previously showed that aldehyde …

Tumor angiogenesis plays a vital role in tumor growth and metastasis. It is proven that in
tumor vasculature, endothelial cells (ECs) originate from a small population of cancer cells …

Simple Summary The role of lactate in cancer described by Otto Warburg in 1927 states that
cancer cells uptake high amount of glucose with a marked increase in lactate production …

Simple Summary Accumulating evidence indicates the existence of cancer stem cells
(CSCs) sub-populations which fuel cancer growth and maintain stemness in different …

Acidosis characterizes the microenvironment of most solid tumors and is considered a new
hallmark of cancer. It is mainly caused by both “aerobic” and “anaerobic” glycolysis of …

Lactate generated from pyruvate fuels production of intracellular NAD+ as an end result of
the glycolytic process in tumors. Elevated lactate concentration represents a good indicator …