Under dysbiosis, a gut metabolic disorder, short-chain carboxylic acids (SCCAs) are
secreted to the lumen, affecting colorectal cancer (CRC) development. Butyrate and …

Cancer stem cells (CSCs) are a small and elusive subpopulation of self-renewing cancer
cells with remarkable ability to initiate, propagate, and spread the malignant disease. In …

Lactic acidosis, glucose deprivation and hypoxia are conditions frequently found in solid
tumors because, among other reasons, tumors switch to Warburg effect and secrete high …

BACKGROUND Unraveling the molecular mechanisms that regulate the biology of
metastasis-competent circulating tumor cells (CTCs) is urgently needed to understand …

Side population (SP) cells within tumors are a small fraction of cancer cells with stem-like
properties that can be identified by flow cytometry analysis based on their high ability to …

Cancer stem cells (CSCs) are considered to be the main cause of tumor recurrence,
metastasis, and an unfavorable prognosis. Energy metabolism is closely associated with cell …

Warburg effect is one of the hallmarks of tumor favoring the suppression of normal oxidative
phosphorylation (OxPhos) and the adaptation to hypoxia. In addition to providing continuous …

Solid tumors grow faster and need more glucose than normal tissue; however, due to poor
angiogenesis and excessive growth, tumors remote from blood vessels are always under …

Hypoxia is a common characteristic of many solid tumors that has been associated with
tumor aggressiveness. Limited diffusion of oxygen generates a gradient of oxygen …

Colorectal cancer patients often relapse after chemotherapy, owing to the survival of stem or
progenitor cells referred to as cancer stem cells (CSCs). Although tumor stromal factors are …