Recently, an interesting study published in Cell Metabolism discovered a novel metabolic
interaction between tumors and T cells, identifying that tumor-derived lactate inhibited CD8+ …

Colorectal cancer patients often relapse after chemotherapy, owing to the survival of stem or
progenitor cells referred to as cancer stem cells (CSCs). Although tumor stromal factors are …

Warburg effect is one of the hallmarks of tumor favoring the suppression of normal oxidative
phosphorylation (OxPhos) and the adaptation to hypoxia. In addition to providing continuous …

Solid tumors grow faster and need more glucose than normal tissue; however, due to poor
angiogenesis and excessive growth, tumors remote from blood vessels are always under …

The subpopulation of cancer stem cells (CSCs) within tumor bulk are known for tumor
recurrence and metastasis. CSCs show intrinsic resistance to conventional therapies and …

Hypoxia microenvironment, as a major feature of solid tumors, increases tumors progression
and metastasis. To research whether hypoxia influences the epithelial–mesenchymal …

Communication between tumors and the stroma of tumor-draining lymph nodes (TDLN)
exists before metastasis arises, altering the structure and function of the TDLN niche …

In solid tumors, a decreased oxygen and nutrient supply creates a hypoxic
microenvironment in the central region. This hypoxic condition induces molecular responses …

The rewiring of cellular metabolism is a defining characteristic of cancer, as tumor cells
adapt to acquire essential nutrients from a nutrient-poor environment to sustain their viability …

The altered metabolism and acidic microenvironment plays an important role in promoting
tumor malignant characteristics. A small population of cancer stem cells (CSCs) were …