Solid tumours are dependent on glucose, but are generally glucose‐deprived due to poor
vascularization. Nevertheless, cancer cells can generally survive glucose deprivation better …

The hypoxic environment in tumor is reported to play an important role in pancreatic cancer
progression. The interaction between stromal and cancer cells also contributes to the …

Cancer stem cells (CSC) or tumor-initiating cells represent a small subpopulation of cells
within the tumor bulk that share features with somatic stem cells, such as self-renewal and …

Metabolic abnormalities is a hallmark of cancer. About 100 years ago, Nobel laureate Otto
Heinrich Warburg first described high rate of glycolysis in cancer cells. Recently more and …

While transformation of normal cells to cancer cells is accompanied with a switch from
oxidative phosphorylation (OXPHOS) to aerobic glycolysis, it is interesting to ask if cancer …

Colorectal cancer (CRC) is one of the most common cancers worldwide, which ranks third in
terms of incidence and the second leading cause of cancer-related mortality. Metabolic …

Most cancer‐related deaths result from the progressive growth of metastases. Patients with
peritoneal metastatic (PM) colorectal cancer have reduced overall survival. Currently, it is …

Acidic extracellular pH is a major feature of tumor tissue, extracellular acidification being
primarily considered to be due to lactate secretion from anaerobic glycolysis …

Introduction The irregular vasculature of solid tumors creates hypoxic regions, which are
characterized by cyclic periods of hypoxia and reoxygenation. Accumulated evidence …

Substantial evidence suggests that the epithelial-mesenchymal transition (EMT) phenotype
is associated with the invasive characteristics of cancer stem cells (CSCs), which possess …