Peripheral sensorineural hearing loss is a very common inner ear disorder affecting nearly
10% of the population. At present there is no cure for this disorder but gene therapy has …

Objectives/Hypothesis Gene therapy offers the possibility of delivering corrective genetic
materials to the cochlea, potentially improving hearing. In animals, the most commonly used …

Background Several genes are candidates for treating inner ear diseases. For clinical
applications, minimally invasive approaches to the inner ear are desirable along with …

Development of a viral vector that can infect hair cells of the cochlea without producing viral-
associated ototoxic effects is crucial for utilizing gene replacement therapy as a treatment for …

This article presents a unique approach for the delivery of gene therapy vectors into the
cochlea of the laboratory rat. Mice and guinea pigs are established in vivo models for …

Gene therapy using virus vectors to treat hereditary diseases has made remarkable
progress in the past decade. There are FDA-approved products for ex-vivo gene therapy for …

Background: Gene therapy may provide a way to restore cochlear function to deaf patients.
The most successful techniques for cochlear gene therapy have been injection of early …

Cochlear gene transfer is a promising new approach for inner ear therapy. Previous studies
have demonstrated hair cell protection with cochlear gene transfer not only in the inoculated …

Gene transfer is an exciting new tool in medical therapy and scientific investigation, but only
very recently has it begun to be developed in the auditory system. This paper describes in …

There are a number of genetic diseases that affect the cochlea early in life, which require
normal gene transfer in the early developmental stage to prevent deafness. The delivery of …