More than 28 million Americans suffer from various forms of hearing loss. The lack of
effective treatments for many forms of hearing disorders has prompted interest in the …

Hearing loss, including genetic hearing loss, is one of the most common forms of sensory
deficits in humans with limited options of treatment. Adeno-associated virus (AAV)-mediated …

The adeno-associated virus (AAV), inoculated into the perilymph, has been shown to be an
effective vector for mediating intracochlear transgene expression. The unexpected finding of …

Adeno-associated virus (AAV) integrated transgene expression within guinea pig cochlea
has been previously documented. This article extends these studies by characterizing the …

Inner ear gene therapy using adeno-associated viral vectors (AAV) promises to alleviate
hearing and balance disorders. We previously established the benefits of Anc80L65 in …

Viral delivery of exogenous coding sequences into the inner ear has the potential for
therapeutic benefit for patients suffering genetic or acquired hearing loss. To devise …

Hypothesis: Adeno-associated virus (AAV) is a suitable viral vector for transgene expression
within the mammalian vestibular organs. Background: In vivo introduction and expression of …

Inner ear gene therapy using adeno-associated viral vectors (AAVs) in neonatal mice can
alleviate hearing loss in mouse models of deafness. However, efficient and safe transgene …

This study was designed to determine whether Coxsackie adenovirus receptor (CAR) and
ανβ3/ανβ5 integrin co-receptors are involved in adenovirus gene transfer in the rat cochlea …

Sensorineural hearing loss is one of the most common sensory disorders worldwide. Recent
advances in vector design have paved the way for investigations into the use of adeno …