This chapter deals with the application of fluorescence in situ hybridization (FISH) to study
interphase nuclei from patients with chronic myeloid leukemia (CML). In our experience …

Metaphase DNA fluorescence in situ hybridization (metaphase‐FISH) was performed on
follow‐up samples from 60 patients suffering from haemopoietic malignancies (acute and …

Interferon-alpha (IFN-alpha) induces cytogenetic responses of variable degree in patients
with chronic myelogenous leukemia (CML). We sought to establish the relationship between …

We analysed 459 samples from 206 chronic myeloid leukaemia (CML) patients at diagnosis
and during or after treatment with interferon‐α (IFN‐α) by quantitative Southern blot analysis …

Cytogenetic, interphase fluorescent in situ hybridization (FISH) and RT-PCR methods were
used to study minimal residual disease in peripheral blood stem cells collected for …

We describe the use of the fluorescence in situ hybridization (FISH) technique to detect
residual Philadelphia chromosome-positive (Ph+) cells in a patient with blastic phase …

Cytogenetic analysis is the gold standard for the follow‐up of CML patients. The sensitivity of
cytogenetics is fairly similar to that of Southern detection of M‐BCR rearrangement (5%); this …

Interferon-alpha (IFN-alpha) has become a widely used treatment modality in chronic
myelogenous leukemia (CML) and was shown to induce complete hematologic responses …

Interferon α (IFN-α) induces cytogenetic responses of variable degree in patients with CML.
We sought to establish the relationship between BCR-ABL transcript numbers measured by …

The molecular hallmark of chronic myeloid leukemia (CML) is the BCR-ABL fusion gene,
which usually results from at (9; 22). Eighty-five percent of CML cases demonstrate this …