The systematic modification of natural products through diverted total synthesis is a powerful
concept for the systematic modification of natural products with the aim of studying …

Taking it easy: Natural product synthesis is a stressful task. Exploiting the understanding of
biosynthetic pathways and implementing genetic engineering into the synthetic chemist's …

In this article strategies for the design and synthesis of natural product analogues are
summarized and illustrated with some selected examples. Proven strategies include …

Covering: 1970 to 2020 By definition total synthesis is the art and science of making the
molecules of living Nature in the laboratory, and by extension, their analogues. Although …

Selected natural products have long been considered as desirable targets for total synthesis
due to their unique biological properties and their challenging structural complexity …

The appealing beauty of the routes that Nature uses to build natural products is breathtaking
and the quest for laboratory syntheses that mimic these routes is longstanding. Since Robert …

Which compound classes are best suited as probes and tools for chemical biology research
and as inspiration for medicinal chemistry programs? Chemical space is enormously large …

Many natural products have remarkable biological functions due to their fascinating
molecular architectures. Despite many advances in synthetic method development, the …

Total synthesis of natural products has been an important pursuit in chemical synthesis due
to their fascinating structural complexity and/or interesting biological activities. In most …

The advent of organic synthesis and the understanding of the molecule as they occurred in
the nineteenth century and were refined in the twentieth century constitute two of the most …