Objective Soluble guanylate cyclase (sGC) is a key enzyme of the nitric oxide–cyclic
guanosine 3′, 5′-monophosphate (NO–cGMP) signaling pathway, and its …

Rationale: Chronic obstructive pulmonary disease (COPD) is a major cause of death
worldwide. No therapy stopping progress of the disease is available. Objectives: To …

We have analyzed the effect of the soluble guanylate cyclase (sGC) stimulator BAY 41-2272
in a therapeutic intervention in guinea pigs chronically exposed to cigarette smoke (CS). The …

Rationale: Soluble guanylyl cyclase (sGC), a cyclic guanosine 5′-monophosphate–
generating enzyme, regulates smooth muscle tone and exerts antiinflammatory effects in …

Background—Nitric oxide (NO) activates soluble guanylate cyclase (sGC), a heterodimer
composed of α-and β-subunits, to produce cGMP. NO reduces pulmonary vascular …

Skeletal muscle dysfunction in chronic obstructive pulmonary disease (COPD) is
characterized by a significant reduction in muscle strength and endurance. Preclinical …

Skeletal muscle dysfunction in chronic obstructive pulmonary disease (COPD) is
characterized by a significant reduction in muscle strength and endurance. Preclinical …

We have examined the effects of exposing rats to hypoxia (10% fractional inspired O2
concentration) for 2 and 7 days on endothelium-dependent and-independent vasodilation …

Inspiratory resistive breathing (RB), encountered in obstructive lung diseases, induces lung
injury. The soluble guanylyl cyclase (sGC)/cyclic guanosine monophosphate (cGMP) …

Background Pulmonary fibrosis (PF) is an increasing cause of morbidity and mortality with
five million people affected worldwide and a median survival time of less than three years …