Poor antibody validation is a challenge in biomedical research: a case study for detection of c-FLIP

O Bucur, B Pennarun, AL Stancu, M Nadler, MS Muraru… - Apoptosis, 2013 - Springer
Successful translation of findings derived from preclinical studies into effective therapies is
critical in biomedical research. Lack of robustness and reproducibility of the preclinical data …

[HTML][HTML] c-FLIP, a master anti-apoptotic regulator

AR Safa - Experimental oncology, 2012 - ncbi.nlm.nih.gov
Abstract Cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein (c-FLIP) is a
master anti-apoptotic regulator and resistance factor that suppresses tumor necrosis factor-α …

Constitutive expression of murine c-FLIPR causes autoimmunity in aged mice

F Ewald, M Annemann, MC Pils, C Plaza-Sirvent… - Cell Death & …, 2014 - nature.com
Death receptor-mediated apoptosis is a key mechanism for the control of immune responses
and dysregulation of this pathway may lead to autoimmunity. Cellular FLICE-inhibitory …

The caspase-8 modulator c-FLIP

T Kataoka - Critical Reviews™ in Immunology, 2005 - dl.begellhouse.com
Death receptors belong to the tumor necrosis factor receptor superfamily and can induce
apoptosis through activation of procaspase-8. The cellular FLICE-inhibitory protein (c-FLIP) …

Knockdown of c‐FLIPL enhanced AD5‐10 anti‐death receptor 5 monoclonal antibody‐induced apoptosis in human lung cancer cells

F Chen, J Guo, Y Zhang, Y Zhao, N Zhou, S Liu… - Cancer …, 2009 - Wiley Online Library
It is reported that the agonistic antibodies against death receptors 4 and 5 (DR4, DR5) are
cytotoxic to various cancer cells. In the present study, the sensitivity of five human lung …

[HTML][HTML] c-FLIP, a novel biomarker for cancer prognosis, immunosuppression, Alzheimer's disease, chronic obstructive pulmonary disease (COPD), and a rationale …

AR Safa, K Kamocki, MR Saadatzadeh… - Biomarkers …, 2019 - ncbi.nlm.nih.gov
Dysregulation of c-FLIP (cellular FADD-like IL-1β-converting enzyme inhibitory protein) has
been shown in several diseases including cancer, Alzheimer's disease, and chronic …

The role of c-FLIP splice variants in urothelial tumours

F Ewald, N Ueffing, L Brockmann, C Hader… - Cell death & …, 2011 - nature.com
Deregulation of apoptosis is common in cancer and is often caused by overexpression of
anti-apoptotic proteins in tumour cells. One important regulator of apoptosis is the cellular …

[HTML][HTML] Roles of c-FLIP in apoptosis, necroptosis, and autophagy

AR Safa - Journal of carcinogenesis & mutagenesis, 2013 - ncbi.nlm.nih.gov
Abstract Cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein (c-FLIP) is a
major antiapoptotic protein and an important cytokine and chemotherapy resistance factor …

The Identification of New c-FLIP Inhibitors for Restoring Apoptosis in TRAIL-Resistant Cancer Cells

K Yaacoub, R Pedeux, P Lafite, U Jarry… - Current Issues in …, 2024 - mdpi.com
The catalytically inactive caspase-8-homologous protein, c-FLIP, is a potent antiapoptotic
protein highly expressed in various types of cancers. c-FLIP competes with caspase-8 for …

High level of cFLIP correlates with resistance to death receptor-induced apoptosis in bladder carcinoma cells.

G Jönsson, S Paulie, A Grandien - Anticancer research, 2003 - europepmc.org
Background The cellular form of FLICE-inhibitory protein (cFLIP) blocks death receptor-
induced apoptosis and has been implicated in tumour progression. cFLIP interacts with …