Neutrophils migrate to infected mucosal sites that they protect against invading pathogens.
Their interaction with the epithelial barrier is controlled by CXC chemokines and by their …

Publisher Summary This chapter discusses the in vitro and in vivo activity and
pathophysiology of human interleukin-8 and related peptides. Interleukin-8 is a member of a …

LPS stimulates human monocytes and neutrophils to produce IL-1 beta and IL-1 receptor
antagonist (IL-1ra). IL-10 has been shown to inhibit LPS-induced IL-1 beta production in …

Forty critically ill surgical patients with documented infections were studied during their stay
in an intensive care unit. Among these patients, 19 developed septic shock and 16 died, 9 of …

Human blood monocytes synthesize but do not secrete IL-1 beta in response to low doses of
bacterial cell-wall products. With this observation, we have developed a two-step staged …

Human endothelial cells and dermal fibroblasts both expressed a membrane-associated
interleukin 1 (IL-1) activity when stimulated with either recombinant tumor necrosis factor …

Interleukin 1 is a polypeptide cytokine produced by various cell types and has been shown
to have a major role in inflammatory and immunological responses. In experimental colitis it …

Endothelial cells are a potent source of hematopoietic growth factors when stimulated by
soluble products of monocytes. Interleukin 1 (IL 1) is released by activated monocytes and is …

Neutrophil recruitment and activation are thought to play an important role in tissue damage
observed in septicemia. Interleukin-8 (IL-8) is a small cytokine with important neutrophil …

Hybridoma growth factor (HGF) is a 20-25 kD protein, supporting the growth of hybridoma
cells in vitro and capable of replacing feeder cells. It was shown to be produced by human …