Chemogenetics is an approach for engineering proteins to enable their modulation by
otherwise inert small molecules. Although kinases, enzymes and ion channels have been …

Chemogenetics is the process of genetically expressing a macromolecule receptor capable
of modulating the activity of the cell in response to selective chemical ligand. This chapter …

Recent developments in chemogenetic approaches to the investigation of brain function
have ushered in a paradigm change in the strategy for drug and behavior research and …

Modern developments in organic chemistry, molecular biology, virology, and genetics have
opened new, exciting possibilities to better understand physiology and to create innovative …

Chemogenetic technologies enable selective pharmacological control of specific cell
populations. An increasing number of approaches have been developed that modulate …

The last decade has seen major advances in neuroscience tools allowing us to selectively
modulate cellular pathways in freely moving animals. Chemogenetic approaches such as …

Elucidating the roles of neuronal cell types for physiology and behavior is essential for
understanding brain functions. Perturbation of neuron electrical activity can be used to probe …

The use of designer receptors exclusively activated by designer drugs (DREADDs) has led
to significant advances in our understanding of the neural circuits that govern behavior. By …

Insights into the role astrocytes and microglia play in normal and diseased brain functioning
has expanded drastically over the last decade. Recently, chemogenetic tools have emerged …

Chemogenetic strategies have emerged as reliable tools for remote control of neuronal
activity. Among these, designer receptors exclusively activated by designer drugs …