Mammalian brains generate internal activity independent of environmental stimuli. Internally
generated states may bring about distinct cortical processing modes. To investigate how …

Cortical neurons process information on a background of spontaneous, ongoing activity with
distinct spatiotemporal profiles defining different cortical states. During wakefulness, cortical …

The wake-sleep cycle, a spontaneous succession of global brain states that correspond to
major overt behaviors, occurs in all higher vertebrates. The transitions between these states …

In this first intracellular study of neocortical activities during waking and sleep states, we
hypothesized that synaptic activities during natural states of vigilance have a decisive impact …

Switches between different behavioral states of the animal are associated with prominent
changes in global brain activity, between sleep and wakefulness or from inattentive to …

The level of arousal in mammals is correlated with metabolic state and specific patterns of
cortical neuronal responsivity. In particular, rhythmic transitions between periods of high …

Neural activity in the sensory cortex combines stimulus responses and ongoing activity, but it
remains unclear whether these reflect the same underlying dynamics or separate processes …

Sleep exerts many effects on mammalian forebrain networks, including homeostatic effects
on both synaptic strengths and firing rates. We used large-scale recordings to examine the …

Homeostatic mechanisms stabilize neural circuit function by keeping firing rates within a set-
point range, but whether this process is gated by brain state is unknown. Here, we monitored …

Neural activity and behavior are both notoriously variable, with responses differing widely
between repeated presentation of identical stimuli or trials. Recent results in humans and …