Plasmid-encoded Pgp3 is a major virulence factor for Chlamydia muridarum to induce hydrosalpinx in mice
Hydrosalpinx induction in mice by Chlamydia muridarum infection, a model that has been
used to study C. trachomatis pathogenesis in women, is known to depend on the cryptic …
used to study C. trachomatis pathogenesis in women, is known to depend on the cryptic …
Plasmid-Encoded Pgp5 Is a Significant Contributor to Chlamydia muridarum Induction of Hydrosalpinx
We have previously shown that the plasmid-encoded Pgp3 is a major virulence factor for C.
muridarum induction of hydrosalpinx. We now report that Pgp5 also plays a significant role …
muridarum induction of hydrosalpinx. We now report that Pgp5 also plays a significant role …
Transformation of Chlamydia muridarum reveals a role for Pgp5 in suppression of plasmid-dependent gene expression
Transformation of Chlamydia trachomatis should greatly advance the chlamydial research.
However, significant progress has been hindered by the failure of C. trachomatis to induce …
However, significant progress has been hindered by the failure of C. trachomatis to induce …
The genital tract virulence factor pGP3 is essential for Chlamydia muridarum colonization in the gastrointestinal tract
L Shao, T Zhang, J Melero, Y Huang, Y Liu… - Infection and …, 2018 - Am Soc Microbiol
The cryptic plasmid is essential for Chlamydia muridarum dissemination from the genital
tract to the gastrointestinal (GI) tract. Following intravaginal inoculation, a C. muridarum …
tract to the gastrointestinal (GI) tract. Following intravaginal inoculation, a C. muridarum …
Chlamydial plasmid-dependent pathogenicity
G Zhong - Trends in microbiology, 2017 - cell.com
Most Chlamydia species carry a 7.5 kb plasmid encoding eight open reading frames
conventionally called plasmid glycoproteins 1–8 or pGP1–8. Although the plasmid is not …
conventionally called plasmid glycoproteins 1–8 or pGP1–8. Although the plasmid is not …
Reduced live organism recovery and lack of hydrosalpinx in mice infected with plasmid-free Chlamydia muridarum
L Lei, J Chen, S Hou, Y Ding, Z Yang, H Zeng… - Infection and …, 2014 - Am Soc Microbiol
Plasmid-free Chlamydia trachomatis and Chlamydia muridarum fail to induce severe
pathology. To evaluate whether the attenuated pathogenicity is due to insufficient infection …
pathology. To evaluate whether the attenuated pathogenicity is due to insufficient infection …
The Plasmid-Encoded pGP3 Promotes Chlamydia Evasion of Acidic Barriers in Both Stomach and Vagina
T Zhang, Z Huo, J Ma, C He, G Zhong - Infection and immunity, 2019 - Am Soc Microbiol
Although Chlamydia trachomatis is a human genital tract pathogen, chlamydial organisms
have frequently been detected in both vaginal and rectal swab samples of animals and …
have frequently been detected in both vaginal and rectal swab samples of animals and …
Plasmid-mediated transformation tropism of chlamydial biovars
L Song, JH Carlson, B Zhou, K Virtaneva… - Pathogens and …, 2014 - academic.oup.com
Chlamydia trachomatis and C. muridarum are human and mouse pathogens, respectively,
which show high conservation of gene order and content. Both species contain a common …
which show high conservation of gene order and content. Both species contain a common …
Chlamydia trachomatis plasmid-encoded Pgp4 is a transcriptional regulator of virulence-associated genes
Chlamydia trachomatis causes chronic inflammatory diseases of the eye and genital tract
and has global medical importance. The chlamydial plasmid plays an important role in the …
and has global medical importance. The chlamydial plasmid plays an important role in the …
Complement factor C5 but not C3 contributes significantly to hydrosalpinx development in mice infected with Chlamydia muridarum
Z Yang, T Conrad, Z Zhou, J Chen, P Dutow… - Infection and …, 2014 - Am Soc Microbiol
Hydrosalpinx is a pathological hallmark of tubal infertility associated with chlamydial
infection. However, the mechanisms of hydrosalpinx remain unknown. Here, we report that …
infection. However, the mechanisms of hydrosalpinx remain unknown. Here, we report that …