Reprogramming energy metabolism, such as enhanced glycolysis, is an Achilles' heel in
cancer treatment. Most studies have been performed on isolated cancer cells. Here, we …

Reprogramming of energy metabolism and evading immune are two emerging hallmarks of
cancers. Accumulating evidence suggest that reprogrammed energy metabolism contributes …

Changes in cellular metabolism involving fuel sources are well-known mechanisms of
cancer cell differentiation in the context of carcinogenesis. Metabolic reprogramming is …

To sustain their high proliferation rates, most cancer cells rely on glycolytic metabolism, with
production of lactic acid. For many years, lactate was seen as a metabolic waste of glycolytic …

Metabolism is central to energy generation and cell signaling in all life forms. Cancer cells
rely heavily on glucose metabolism wherein glucose is primarily converted to lactate even in …

Metabolic reprogramming is one of fourteen hallmarks of tumor cells, among which aerobic
glycolysis, often known as the “Warburg effect,” is essential to the fast proliferation and …

Malignant transformation of cells leads to enhanced glucose uptake and the conversion of a
larger fraction of pyruvate into lactate, even under normoxic conditions; this phenomenon of …

Lactate, once recognized as a wasty product from anaerobic glycolysis, is proved to be a
pivotal signal molecule. Lactate accumulation occurs in diverse physiological and …

Metabolic abnormalities is a hallmark of cancer. About 100 years ago, Nobel laureate Otto
Heinrich Warburg first described high rate of glycolysis in cancer cells. Recently more and …

Recently, an interesting study published in Cell Metabolism discovered a novel metabolic
interaction between tumors and T cells, identifying that tumor-derived lactate inhibited CD8+ …