Nephrotoxicity assessments of benzo (a) pyrene during zebrafish embryogenesis

KC Lo, CY Sun, YJ Ding, JN Tsai, KP Chang… - Research on Chemical …, 2014 - Springer
Benzo (a) pyrene is a chemical produced during the process of making fried, roasted, and
smoked foods. It remains unclear whether benzo (a) pyrene affects the early development of …

Tissue Distribution and Metabolism of Benzo[a]pyrene in Embryonic and Larval Medaka (Oryzias latipes)

MW Hornung, PM Cook, PN Fitzsimmons… - Toxicological …, 2007 - academic.oup.com
The need to understand chemical uptake, distribution, and metabolism in embryonic and
larval fish derives from the fact that these early life stages often exhibit greater sensitivity to …

Exposure to low dose benzo [a] pyrene during early life stages causes symptoms similar to cardiac hypertrophy in adult zebrafish

L Huang, D Gao, Y Zhang, C Wang, Z Zuo - Journal of hazardous materials, 2014 - Elsevier
Growing evidence indicates that polycyclic aromatic hydrocarbons (PAHs) can lead to
cardiac hypertrophy and recent research indicates that exposure to low dose crude oil …

Mechanistic evaluation of benzo [a] pyrene's developmental toxicities mediated by reduced Cyp19a1b activity

KM Alharthy, FF Albaqami, C Thornton… - Toxicological …, 2017 - academic.oup.com
Benzo [a] pyrene (BaP) is a ubiquitous environmental contaminant that is both an endocrine
disruptor and a carcinogen. Aromatase (CYP19) is a key enzyme in steroidogenesis that is …

Low-level pyrene exposure causes cardiac toxicity in zebrafish (Danio rerio) embryos

Y Zhang, C Wang, L Huang, R Chen, Y Chen, Z Zuo - Aquatic toxicology, 2012 - Elsevier
It is widely accepted that the most abundant polycyclic aromatic hydrocarbons (PAHs) in
weathered crude oils is cardiotoxic. Although PAHs toxic endpoints show strong correlation …

Protective effects of genistein and estradiol on PAHs-induced developmental toxicity in zebrafish embryos

X Ren, F Lu, Y Cui, X Wang, C Bai… - Human & …, 2012 - journals.sagepub.com
The toxicity of exposure to polycyclic aromatic hydrocarbons (PAHs) or phytoestrogen is
relatively well characterized. However, the toxicity of combined exposure to PAHs and …

Multigenerational effects of benzo [a] pyrene exposure on survival and developmental deformities in zebrafish larvae

J Corrales, C Thornton, M White, KL Willett - Aquatic toxicology, 2014 - Elsevier
In the aquatic environment, adverse outcomes from dietary polycyclic aromatic hydrocarbon
(PAH) exposure are poorly understood, and multigenerational developmental effects …

Altered gene expression: A mechanism for reproductive toxicity in zebrafish exposed to benzo [a] pyrene

JL Hoffmann, JT Oris - Aquatic Toxicology, 2006 - Elsevier
Exposure of fish to polycyclic aromatic hydrocarbons (PAHs) has consistently been shown to
have a negative impact on reproduction (eg decreased spawning success, decreased …

Transcriptomic changes in zebrafish embryos and larvae following benzo [a] pyrene exposure

X Fang, J Corrales, C Thornton, T Clerk… - Toxicological …, 2015 - academic.oup.com
Abstract Benzo [a] pyrene (BaP) is an environmentally relevant carcinogenic and endocrine
disrupting compound that causes immediate, long-term, and multigenerational health …

Embryonic exposure to benzo (a) pyrene inhibits reproductive capability in adult female zebrafish and correlation with DNA methylation

D Gao, J Lin, K Ou, Y Chen, H Li, Q Dai, Z Yu… - Environmental …, 2018 - Elsevier
This study was conducted to investigate the effects of embryonic short-term exposure to
benzo (a) pyrene (BaP), a model polycyclic aromatic hydrocarbon, on ovarian development …