Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death

L Chen, B Xu, L Liu, Y Luo, H Zhou, W Chen… - Free Radical Biology …, 2011 - Elsevier
Cadmium (Cd), a highly toxic environmental pollutant, induces neurodegenerative diseases.
Recently we have demonstrated that Cd induces neuronal apoptosis in part through …

Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5

L Chen, L Liu, S Huang - Free Radical Biology and Medicine, 2008 - Elsevier
Cadmium (Cd), a highly toxic environmental pollutant, induces neurodegenerative diseases.
Recently we have demonstrated that Cd may induce neuronal apoptosis in part through …

MAPK and mTOR pathways are involved in cadmium‐induced neuronal apoptosis

L Chen, L Liu, Y Luo, S Huang - Journal of neurochemistry, 2008 - Wiley Online Library
Cadmium (Cd) may be accumulated in human body through long‐term exposure to Cd‐
polluted environment, resulting in neurodegeneration and other diseases. To study the …

[HTML][HTML] Calcium signaling is involved in cadmium-induced neuronal apoptosis via induction of reactive oxygen species and activation of MAPK/mTOR network

B Xu, S Chen, Y Luo, Z Chen, L Liu, H Zhou, W Chen… - PloS one, 2011 - journals.plos.org
Cadmium (Cd), a toxic environmental contaminant, induces oxidative stress, leading to
neurodegenerative disorders. Recently we have demonstrated that Cd induces neuronal …

Cadmium activates reactive oxygen species-dependent AKT/mTOR and mitochondrial apoptotic pathways in neuronal cells

Y Yan, W Yi, FF Hu, CY Jiang, YJ Zhang… - Biomedical and …, 2016 - Elsevier
Objective To examine the role of Cd-induced reactive oxygen species (ROS) generation in
the apoptosis of neuronal cells. Methods Neuronal cells (primary rat cerebral cortical …

Rapamycin ameliorates cadmium-induced activation of MAPK pathway and neuronal apoptosis by preventing mitochondrial ROS inactivation of PP2A

C Xu, X Wang, Y Zhu, X Dong, C Liu, H Zhang, L Liu… - …, 2016 - Elsevier
Cadmium (Cd) is a highly toxic metal that affects the central nervous system. Recently we
have demonstrated that inhibition of mTOR by rapamycin rescues neuronal cells from Cd …

Redox regulates COX-2 upregulation and cell death in the neuronal response to cadmium

P Rockwell, J Martinez, L Papa, E Gomes - Cellular signalling, 2004 - Elsevier
We reported previously that cadmium, an oxidative stressor, induced cyclooxygenase-2
(COX-2) upregulation in mouse neuronal cells that culminated in cell death. Herein, we …

CaMKII is involved in cadmium activation of MAPK and mTOR pathways leading to neuronal cell death

S Chen, Y Xu, B Xu, M Guo, Z Zhang… - Journal of …, 2011 - Wiley Online Library
J. Neurochem.(2011) 119, 1108–1118. Abstract Cadmium (Cd), a toxic environmental
contaminant, induces neurodegenerative diseases. Recently, we have shown that Cd …

N‐acetyl‐L‐cysteine protects against cadmium‐induced neuronal apoptosis by inhibiting ROS‐dependent activation of A kt/m TOR pathway in mouse brain

S Chen, Q Ren, J Zhang, Y Ye, Z Zhang… - Neuropathology and …, 2014 - Wiley Online Library
Aims This study explores the neuroprotective effects and mechanisms of N‐acetyl‐L‐
cysteine (NAC) in mice exposed to cadmium (C d). Methods NAC (150 mg/kg) was …

[HTML][HTML] Cadmium-induced oxidative stress: focus on the central nervous system

JJV Branca, C Fiorillo, D Carrino, F Paternostro… - Antioxidants, 2020 - mdpi.com
Cadmium (Cd), a category I human carcinogen, is a well-known widespread environmental
pollutant. Chronic Cd exposure affects different organs and tissues, such as the central …