HER2 (human epidermal growth factor receptor 2) receptor is a membrane tyrosine kinase
and when activated affects cell proliferation and survival. The HER2 oncogene is located on …

Human epidermal growth factor receptor 2 (HER2) protein overexpression and/or HER2
gene amplification is found in about 20% of invasive breast cancers. It is a sole predictive …

It has been over 20 years since the discovery of the human epidermal growth factor receptor
2 (HER2), a tyrosine kinase receptor that is a potent oncoprotein in breast and other cancers …

Human epidermal growth factor receptor 2 (HER2) is an important prognostic and predictive
factor in breast cancer. HER2 is overexpressed in approximately 15%–20% of invasive …

Context—HER2 is a membrane tyrosine kinase and oncogene that is overexpressed and
gene amplified in about 20% of breast cancers. When activated it provides the cell with …

In recent years investigators have looked at the human epidermal growth factor receptor-2
(HER2), which is overexpressed in 20%–30% of breast cancer patients, with regard to its …

The HER2/neu proto-oncogene encodes a 185-kd transmembrane receptor with tyrosine
kinase activity. Amplification of HER2 with overexpression of the p185HER2 receptor occurs …

HER2 overexpression and anti-HER2 agents represent probably the best story of success of
individualized therapy in breast cancer. Due to the important therapeutic implications, the …

The human epidermal growth factor receptor (HER) family comprises four homologous
members. The activation of these receptors affects essential tumorigenic processes and …

The high incidence of HER2 overexpression on the cell surface of breast cancer cells and
the recognized prognostic and potentially predictive value of HER2 render this cell surface …