[PDF][PDF] DNA demethylation dynamics in the human prenatal germline
Global DNA demethylation in humans is a fundamental process that occurs in pre-
implantation embryos and reversion to naive ground state pluripotent stem cells (PSCs) …
implantation embryos and reversion to naive ground state pluripotent stem cells (PSCs) …
[PDF][PDF] The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells
Genome-wide DNA methylation reprogramming occurs in mouse primordial germ cells
(PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are …
(PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are …
[HTML][HTML] Genome-wide analysis of DNA methylation dynamics during early human development
H Okae, H Chiba, H Hiura, H Hamada, A Sato… - PLoS …, 2014 - journals.plos.org
DNA methylation is globally reprogrammed during mammalian preimplantation
development, which is critical for normal development. Recent reduced representation …
development, which is critical for normal development. Recent reduced representation …
High-resolution DNA methylome analysis of primordial germ cells identifies gender-specific reprogramming in mice
H Kobayashi, T Sakurai, F Miura, M Imai… - Genome …, 2013 - genome.cshlp.org
Dynamic epigenetic reprogramming occurs during mammalian germ cell development,
although the targets of this process, including DNA demethylation and de novo methylation …
although the targets of this process, including DNA demethylation and de novo methylation …
Global profiling of DNA methylation erasure in mouse primordial germ cells
S Guibert, T Forné, M Weber - Genome research, 2012 - genome.cshlp.org
Epigenetic reprogramming, characterized by loss of cytosine methylation and histone
modifications, occurs during mammalian development in primordial germ cells (PGCs), yet …
modifications, occurs during mammalian development in primordial germ cells (PGCs), yet …
[PDF][PDF] A unique gene regulatory network resets the human germline epigenome for development
Resetting of the epigenome in human primordial germ cells (hPGCs) is critical for
development. We show that the transcriptional program of hPGCs is distinct from that in …
development. We show that the transcriptional program of hPGCs is distinct from that in …
[PDF][PDF] FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency
Genome-wide erasure of DNA methylation takes place in primordial germ cells (PGCs) and
early embryos and is linked with pluripotency. Inhibition of Erk1/2 and Gsk3β signaling in …
early embryos and is linked with pluripotency. Inhibition of Erk1/2 and Gsk3β signaling in …
Single-cell methylome landscapes of mouse embryonic stem cells and early embryos analyzed using reduced representation bisulfite sequencing
DNA methylation is crucial for a wide variety of biological processes, yet no technique
suitable for the methylome analysis of DNA methylation at single-cell resolution is available …
suitable for the methylome analysis of DNA methylation at single-cell resolution is available …
Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway
P Hajkova, SJ Jeffries, C Lee, N Miller, SP Jackson… - Science, 2010 - science.org
Genome-wide active DNA demethylation in primordial germ cells (PGCs), which reprograms
the epigenome for totipotency, is linked to changes in nuclear architecture, loss of histone …
the epigenome for totipotency, is linked to changes in nuclear architecture, loss of histone …
[HTML][HTML] Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes
CR Farthing, G Ficz, RK Ng, CF Chan, S Andrews… - PLoS …, 2008 - journals.plos.org
DNA methylation patterns are reprogrammed in primordial germ cells and in preimplantation
embryos by demethylation and subsequent de novo methylation. It has been suggested that …
embryos by demethylation and subsequent de novo methylation. It has been suggested that …