DNA methylation is one of the best-known epigenetic modifications in mammals. The
alteration of DNA methylation patterns has been found to be related to many diseases …

DNA hypomethylation was the initial epigenetic abnormality recognized in human tumors.
However, for several decades after its independent discovery by two laboratories in 1983, it …

DNA methylation is one of several epigenetic changes observed in cells. Aberrant
methylation of tumor suppressor genes, proto-oncogenes, and vital cell cycle genes has led …

A much wider variety of biological functions of postreplicative DNA methylation is observed
in prokaryotes than in eukaryotes. In eukaryotes DNA methylation is primarily a means of the …

DNA methylation is an epigenetic mark that living beings have used in different
environments. The MTases family catalyzes DNA methylation. This process is conserved …

Significance: Methylation of cytosine in DNA is linked with gene regulation, and this has
profound implications in development, normal biology, and disease conditions in many …

DNA methylation has long been considered a very stable DNA modification in mammals that
could only be removed by replication in the absence of remethylation–that is, by mere …

DNA methylation is now recognized as an important mechanism regulating different
functions of the genome; gene expression, replication, and cancer. Different factors control …

DNA methylation is catalyzed by a family of conserved DNA methyltransferases and is
widespread among protists, plants, fungi and animals. It is however absent in some species …

DNA methylation is one of the most extensively studied epigenetic marks. It is involved in
transcriptional gene silencing and plays important roles during mammalian development. Its …