During differentiation and development cells undergo dramatic morphological and functional
changes without any change in the DNA sequence. The underlying changes of gene …

Ever since the discovery of DNA methylation at cytosine residues, the role of this so called
fifth base has been extensively studied and debated. Until recently, the majority of DNA …

The term epigenetic modification denotes reversible traits of gene expression that do not
include alterations to the DNA sequence. These epigenetic alterations are responsible for …

Methylation of DNA at position five of the cytosine ring occurs at most CpG dinucleotides in
the mammalian genome and is essential for embryonic viability. With several of the key …

Methylation of cytosines within the CpG dinucleotide by DNA methyltransferases is involved
in regulating transcription and chromatin structure, controlling the spread of parasitic …

DNA methylation is an epigenetic modification which plays an important role in chromatin
organization and gene expression. DNA methylation can silence genes and repetitive …

DNA methylation is one of the most extensively studied epigenetic marks. It is involved in
transcriptional gene silencing and plays important roles during mammalian development. Its …

The ability to exogenously impose targeted epigenetic changes in the genome represents
an attractive route for the simulation of genomic de novo epigenetic events characteristic of …

DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

In mammals, CpG methylation patterns are established and maintained during development
by the Dnmt1 and Dnmt3 families of DNA methyltransferases. These enzymes share …