Development of novel antimicrobial agents is a top priority in the fight against multidrug-
resistant (MDR) and persistent bacteria. We developed a panel of synthetic antimicrobial …

Host defense (antimicrobial) peptides, produced by all complex organisms, typically contain
an abundance of positively charged and hydrophobic amino acid residues. A small synthetic …

Acinetobacter baumannii infections are difficult to treat due to multidrug resistance. Biofilm
formation by A. baumannii is an additional factor in its ability to resist antimicrobial therapy …

AR-23 is a melittin-related peptide with 23 residues. Like melittin, its high α-helical
amphipathic structure results in strong bactericidal activity and cytotoxicity. In this study, a …

Methicillin-resistant Staphylococcus aureus (MRSA) infections present a serious challenge
because of the emergence of resistance to numerous conventional antibiotics. Due to their …

Abstract Treatment of Staphylococcus aureus infections continues to be a challenge due to
antimicrobial resistance. Endogenous antimicrobial peptides may offer a new option for …

Cationic amphipathic peptides have been extensively investigated as a potential source of
new antimicrobials that can complement current antibiotic regimens in the face of emerging …

The incorporation of the innate immune system into humans is essential for survival and
health due to the rapid replication of invading microbes and the delayed action of the …

The escalating threat of antimicrobial resistance has increased pressure to develop novel
therapeutic strategies to tackle drug-resistant infections. Antimicrobial peptides have …

The emergence of multiple-drug-resistant (MDR) bacterial pathogens in hospitals
(nosocomial infections) presents a global threat of growing importance, especially for Gram …